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Correlates of treatment engagement and client outcomes results of a randomised controlled trial of nabiximols for the treatment of cannabis use disorder1.20 MB
Published VersionCC BY V4.0, Open Access
Journal article
Correlates of treatment engagement and client outcomes: results of a randomised controlled trial of nabiximols for the treatment of cannabis use disorder
Substance Abuse Treatment, Prevention, and Policy, Vol.17(1), pp.1-12
2022
PMCID: PMC9548192
PMID: 36209081
Appears in Thompson Institute Research Collection
Abstract
Introduction and aims: There is increasing interest and evidence for the use of cannabinoid medications in the treatment of cannabis use disorder, but little examination of the correlates of successful treatment. This paper is a secondary analysis of a randomised placebo controlled trial of nabiximols for the treatment of cannabis use disorder (CUD), aiming to identify which client and treatment characteristics impact treatment engagement and outcomes. Method: Bayesian multiple regression models were used to examine the impact of age, gender, duration of regular cannabis use, daily quantity of cannabis, cannabis use problems, self efficacy for quitting, sleep, mental health, pain measures, and treatment group upon treatment engagement (retention, medication dose, and counselling participation) and treatment outcomes (achieving end of study abstinence, and a 50% or greater reduction in cannabis use days) among the 128 clients participating in the 12 week trial. Results: Among the treatment factors, greater counselling attendance was associated with greater odds of abstinence and ≥ 50% reduction in cannabis use; nabiximols with greater odds of ≥ 50% reduction and attending counselling , and reduced hazard of treatment dropout; and higher dose with lower odds of ≥ 50% reduction. Among the client factors, longer duration of regular use was associated with higher odds of abstinence and 50% reduction, and lower hazard of treatment dropout; greater quantity of cannabis use with reduced hazard of dropout, greater odds of attending counselling, and higher average dose; greater pain at baseline with greater odds of ≥ 50% reduction and higher average dose; and more severe sleep issues with lower odds of ≥ 50% reduction. Males had lower odds of attending counselling. Discussions and conclusions: These findings suggest that counselling combined with agonist pharmacotherapy may provide the optimal treatment for cannabis use disorder. Younger clients, male clients, and clients with sleep issues could benefit from extra support from treatment services to improve engagement and outcomes.
Details
- Title
- Correlates of treatment engagement and client outcomes: results of a randomised controlled trial of nabiximols for the treatment of cannabis use disorder
- Authors
- Llewellyn Mills (Corresponding Author) - The University of SydneyAdrian Dunlop (Author) - University of Newcastle AustraliaMark Montebello (Author) - The University of SydneyJan Copeland (Author) - University of the Sunshine Coast, Queensland, Thompson InstituteRaimondo Bruno (Author) - University of TasmaniaMeryem Jefferies (Author) - Sydney Local Health DistrictIain McGregor (Author) - The University of SydneyNicholas Lintzeris (Author) - The University of Sydney
- Publication details
- Substance Abuse Treatment, Prevention, and Policy, Vol.17(1), pp.1-12
- Publisher
- BioMed Central Ltd.
- Date published
- 2022
- DOI
- 10.1186/s13011-022-00493-z
- ISSN
- 1747-597X
- PMID
- 36209081; PMC9548192
- Copyright note
- © The Author(s) 2022. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativeco mmons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
- Organisation Unit
- University of the Sunshine Coast, Queensland; Thompson Institute
- Language
- English
- Record Identifier
- 99678891702621
- Output Type
- Journal article
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