Files and links (1)
Ophthalmic Physiologic Optic - 2020 - Consejo - Corneal tissue properties following scleral lens wear using Scheimpflug1.78 MB
Published VersionCC BY-NC-ND V4.0, Open Access
Journal article
Corneal tissue properties following scleral lens wear using Scheimpflug imaging
Ophthalmic & Physiological Optics, Vol.40(5), pp.595-606
2020
PMID: 32705705
Abstract
Purpose:
To investigate the effect of short-term scleral lens wear on the corneal stroma at a macroscopic (thickness) and microscopic (within tissue) level, including regional variations.
Methods:
Fourteen young, healthy participants wore a rotationally symmetric, 16.5 mm diameter, scleral lens for 8 h. Scheimpflug images were captured before, and immediately after, lens wear, and also on a second day (without lens wear) to quantify natural corneal diurnal variations. After corneal segmentation, pixel intensities of the stromal tissue were statistically modelled using a Weibull probability density function from which parameters α and β were derived.
Results:
Both α and β parameters increased significantly following scleral lens wear (by 5.7 ± 10% and 6.5 ± 6.5%, respectively, both p < 0.01). Corneal thickness also increased slightly following lens wear (mean increase 0.49 ± 1.77%, p = 0.01); however, the change in α and β parameters did not correlate with the magnitude of corneal swelling. On the control day, small but significant corneal thinning was observed (−0.82 ± 1.1%, p = 0.03), while α and β parameters remained stable. Both microparameters varied significantly across the cornea, with α decreasing (−15.4 ± 0.7%) and β increasing towards the periphery (+4.4 ± 2.6%) (both p < 0.001).
Conclusion:
Corneal microparameters α and β varied regionally across the cornea and displayed a statistically significant increase following short-term scleral lens wear, but remained stable between morning and evening measurements taken during a control day without lens wear. These corneal microparameters may be a useful metric to quantify subclinical corneal changes associated with low level hypoxia.
Details
- Title
- Corneal tissue properties following scleral lens wear using Scheimpflug imaging
- Authors
- Alejandra Consejo (Corresponding Author) - Polish Academy of SciencesDavid Alonso-Caneiro (Author) - Queensland University of TechnologyMaciej Wojtkowski (Author) - Polish Academy of SciencesStephen J. Vincent (Author) - Queensland University of Technology
- Publication details
- Ophthalmic & Physiological Optics, Vol.40(5), pp.595-606
- Publisher
- Wiley-Blackwell Publishing Ltd.
- Date published
- 2020
- DOI
- 10.1111/opo.12710
- ISSN
- 1475-1313; 0275-5408
- PMID
- 32705705
- Copyright note
- © 2020 The Authors. Ophthalmic & Physiological Optics published by John Wiley & Sons Ltd on behalf of College of Optometrists Ophthalmic & Physiological Optics. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
- Grant note
- 779960 / European Union; European Union (EU)
- Organisation Unit
- School of Science, Technology and Engineering
- Language
- English
- Record Identifier
- 99973593302621
- Output Type
- Journal article
Metrics
28 Record Views
InCites Highlights
These are selected metrics from InCites Benchmarking & Analytics tool, related to this output
- Collaboration types
- Domestic collaboration
- International collaboration
- Web Of Science research areas
- Ophthalmology