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Published VersionCC BY-NC V4.0, Open Access
Journal article
Convergent evolution of toxin resistance in animals
Biological Reviews, Vol.97(5), pp.1823-1843
2022
PMID: 35580905
Abstract
Convergence is the phenomenon whereby similar phenotypes evolve independently in different lineages. One example is resistance to toxins in animals. Toxins have evolved many times throughout the tree of life. They disrupt molecular and physiological pathways in target species, thereby incapacitating prey or deterring a predator. In response, molecular resistance has evolved in many species exposed to toxins to counteract their harmful effects. Here, we review current knowledge on the convergence of toxin resistance using examples from a wide range of toxin families. We explore the evolutionary processes and molecular adaptations driving toxin resistance. However, resistance adaptations may carry a fitness cost if they disrupt the normal physiology of the resistant animal. Therefore, there is a trade-off between maintaining a functional molecular target and reducing toxin susceptibility. There are relatively few solutions that satisfy this trade-off. As a result, we see a small set of molecular adaptations appearing repeatedly in diverse animal lineages, a phenomenon that is consistent with models of deterministic evolution. Convergence may also explain what has been called 'autoresistance'. This is often thought to have evolved for self-protection, but we argue instead that it may be a consequence of poisonous animals feeding on toxic prey. Toxin resistance provides a unique and compelling model system for studying the interplay between trophic interactions, selection pressures and the molecular mechanisms underlying evolutionary novelties.
Details
- Title
- Convergent evolution of toxin resistance in animals
- Authors
- Jory van Thiel (Corresponding Author) - Leiden UniversityMuzaffar A Khan (Author) - Leiden UniversityRoel M Wouters (Author) - Leiden UniversityRichard Harris (Author) - The University of QueenslandNicholas R Casewell (Author) - Liverpool School of Tropical MedicineBryan G Fry (Author) - The University of QueenslandR Manjunatha Kini (Author) - National University of SingaporeStephen P Mackessy (Author) - University of Northern ColoradoFreek J Vonk (Author) - Naturalis Biodiversity CenterWolfgang Wuster (Author) - Bangor UniversityMichael K Richardson (Corresponding Author) - Leiden University
- Publication details
- Biological Reviews, Vol.97(5), pp.1823-1843
- Publisher
- Wiley-Blackwell Publishing Ltd.
- Date published
- 2022
- DOI
- 10.1111/brv.12865
- ISSN
- 1469-185X; 1464-7931
- PMID
- 35580905
- Copyright note
- This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproductionin any medium, provided the original work is properly cited and is not used for commercial purposes.
- Grant note
- M. A. K. and M. K. R. were supported by Elise Mathilde Fonds of Leids Universiteits Fonds (grant number 6113/21-6-16), Academy Ecology Funds of Royal Netherlands Academy of Arts and Sciences (grant number 713/18015), Higher Education Commission, Islamabad, Pakistan; R. J. H. was supported by the University of Queensland International PhD scholarship fund; and R. M. K. was supported by Ministry of Education, Singapore (grant number MOE2017-T2-1-045).
- Organisation Unit
- Centre for Bioinnovation
- Language
- English
- Record Identifier
- 991177844902621
- Output Type
- Journal article
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