Journal article
Concanavalin A electrochemical sensor based on the surface blocking principle at an ion-selective polymeric membrane
Microchimica Acta, Vol.182(1-2), pp.129-137
2015
Abstract
We report on a new electrochemical sensor for Concanavalin A. It is based on blocking the surface of plasticized PVC membranes that were covalently modified with D-mannose using click chemistry. The interaction of D-mannose with Concanavalin A on the surface perturbs the flux of a marker ion for which the ion-selective membrane is responsive, and this results in a change in the electrochemical signal. The sensor was characterized using a variety of electrochemical protocols, and results were confirmed by quartz crystal microbalance experiments. The lowest limit of detection (10 μg mL-1) was obtained using a membrane containing a cation exchanger and tetrabutylammonium ion as the marker ion. [Figure not available: see fulltext.] © 2014 Springer-Verlag Wien.
Details
- Title
- Concanavalin A electrochemical sensor based on the surface blocking principle at an ion-selective polymeric membrane
- Authors
- M Pawlak (Author) - University of Geneva, SwitzerlandG Mistlberger (Author) - University of Geneva, SwitzerlandEric Bakker (Author) - University of Geneva, Switzerland
- Publication details
- Microchimica Acta, Vol.182(1-2), pp.129-137
- Publisher
- Springer Wien
- Date published
- 2015
- DOI
- 10.1007/s00604-014-1309-3
- ISSN
- 0026-3672
- Organisation Unit
- University of the Sunshine Coast, Queensland
- Language
- English
- Record Identifier
- 99448811202621
- Output Type
- Journal article
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- Web Of Science research areas
- Chemistry, Analytical