Journal article
Comprehensive Landscape of Heparin Therapy for COVID-19
Carbohydrate Polymers, Vol.254, pp.1-10
2021
PMID: 33357843
Appears in COVID-19 Research
Abstract
The pandemic coronavirus disease 2019 (COVID-19), caused by the infection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is rapidly spreading globally. Clinical observations found that systemic symptoms caused by SARS-CoV-2 infection are attenuated when using the anticoagulant agent heparin, indicating that heparin may play other roles in managing COVID-19, in addition to prevention of pulmonary thrombosis. Several biochemical studies show strong binding of heparin and heparin-like molecules to the Spike protein, which resulted in inhibition of viral infection to cells. The clinical observations and in vitro studies argue for a potential multiple-targeting effects of heparin. However, adverse effects of heparin administration and some of the challenges using heparin therapy for SARS-CoV-2 infection need to be considered. This review discusses the pharmacological mechanisms of heparin regarding its anticoagulant, anti-inflammatory and direct antiviral activities, providing current evidence concerning the effectiveness and safety of heparin therapy for this major public health emergency.
Details
- Title
- Comprehensive Landscape of Heparin Therapy for COVID-19
- Authors
- Chen Shi - Huazhong University of Science and TechnologyWu Tingting - Huazhong University of Science and TechnologyJin-Ping Li - Uppsala UniversityMitchell A Sullivan - University of QueenslandCong Wang - Huazhong University of Science and TechnologyHanxiang Wang - Huazhong University of Science and TechnologyBin Deng (Corresponding Author) - Huazhong University of Science and TechnologyYu Zhang (Corresponding Author) - Huazhong University of Science and Technology
- Publication details
- Carbohydrate Polymers, Vol.254, pp.1-10
- Publisher
- Elsevier Ltd
- Date published
- 2021
- DOI
- 10.1016/j.carbpol.2020.117232
- ISSN
- 1879-1344
- PMID
- 33357843
- Grant note
- This work was supported by the National Natural Science Foundation of China [81901884, 81603037]; Natural Science Foundation of Hubei Province [2019CFB490]; Swedish Research Council [2020-05759].
- Organisation Unit
- School of Health - Biomedicine
- Language
- English
- Record Identifier
- 991035094902621
- Output Type
- Journal article
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- Domestic collaboration
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- Web Of Science research areas
- Chemistry, Applied
- Chemistry, Organic
- Polymer Science
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