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Experimental Physiology - 2023 - Ruediger - Comparison of peripheral and cerebral vascular function between premenopausal 409.43 kB
Published VersionCC BY V4.0, Open Access
Journal article
Comparison of peripheral and cerebral vascular function between premenopausal, early and late postmenopausal females
Experimental Physiology, Vol.108(3), pp.518-530
2023
Abstract
The risk of cardiovascular and cerebrovascular disease increases in ageing females, coinciding with the onset of menopause. Differences in peripheral and cerebrovascular function across menopausal stages, however, are poorly characterized. The aim of this study was to compare peripheral and cerebrovascular function between healthy premenopausal (PRE), early (1–6 years after final menstrual period; E-POST) and late (>6 years after final menstrual period; L-POST) postmenopausal females. We also explored the association between reproductive hormones, NO bioavailability and cerebrovascular function. In 39 females (40–65 years of age), we measured arterial stiffness, brachial artery flow-mediated dilatation, and cerebrovascular reactivity (CVR) to hypercapnia in the middle (MCAv) and internal (ICA) carotid arteries. Follicle-stimulating hormone, estradiol, progesterone and plasma nitrate and nitrite concentrations were also measured. Years since final menstrual period (PRE, 0 ± 0 years; E-POST, 3 ± 1 years; L-POST, 11 ± 4 years; P < 0.001) and estradiol levels (PRE, 145.5 ± 65.6 pg ml −1 ; E-POSTm 30.2 ± 81.2 pg ml −1 ; L-POST, 7.7 ± 11.3 pg ml −1 ; P < 0.001) were different between groups. All groups exceeded the guidelines for recommended physical activity. There were no group differences in blood pressure (P = 0.382), arterial stiffness (P = 0.129), flow-mediated dilatation (P = 0.696) or MCAv CVR (P = 0.442). The ICA CVR blood flow response was lower in PRE compared with L-POST (26.5 ± 19.2 vs. 47.8 ± 12.6%; P = 0.010), but after adjusting for age these differences were no longer present. Flow-mediated dilatation (r = 0.313, P = 0.105) and ICA CVR (r = −0.154, P = 0.495) were not associated with the estradiol concentration. There were no associations between the estradiol concentration and NO bioavailability. These results suggest that in healthy, physically active early and late postmenopausal females, vascular and cerebrovascular function is generally well preserved. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Details
- Title
- Comparison of peripheral and cerebral vascular function between premenopausal, early and late postmenopausal females
- Authors
- Stefanie Ruediger (Author) - The University of QueenslandFaith K Pizzey (Author) - The University of QueenslandJodie L Koep (Author) - The University of QueenslandJeff S Coombes (Author) - The University of QueenslandChristopher Askew (Author) - University of the Sunshine Coast, Queensland, School of Health - Sports & Exercise ScienceTom G Bailey (Author) - The University of Queensland
- Publication details
- Experimental Physiology, Vol.108(3), pp.518-530
- Publisher
- Wiley-Blackwell Publishing Ltd.
- Date published
- 2023
- DOI
- 10.1113/EP090813
- ISSN
- 1469-445X; 0958-0670
- Copyright note
- © 2022 The Authors. Experimental Physiology published by John Wiley & Sons Ltd on behalf of The Physiological Society. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
- Organisation Unit
- UniSC Clinical Trials Centre; School of Health and Sport Sciences - Legacy; Cancer Research Cluster; School of Health - Sports & Exercise Science; School of Health and Behavioural Sciences - Legacy
- Language
- English
- Record Identifier
- 99699098302621
- Output Type
- Journal article
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