Comparison of koala LPCoLN and human strains of Chlamydia pneumoniae highlights extended genetic diversity in the species

C M Mitchell; K M Hovis; P M Bavoil; G S A Myers; J A Carrasco; Peter Timms

doi:10.1186/1471-2164-11-442

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Comparison of koala LPCoLN and human strains of Chlamydia pneumoniae highlights extended genetic diversity in the species

Journal article

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Comparison of koala LPCoLN and human strains of Chlamydia pneumoniae highlights extended genetic diversity in the species

C M Mitchell, K M Hovis, P M Bavoil, G S A Myers, J A Carrasco and Peter Timms

BMC Genomics, Vol.11, 442

2010

DOI: https://doi.org/10.1186/1471-2164-11-442

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Abstract

Chlamydia

disease transmission

intervention

Background: Chlamydia pneumoniae is a widespread pathogen causing upper and lower respiratory tract infections in addition to a range of other diseases in humans and animals. Previous whole genome analyses have focused on four essentially clonal (> 99% identity) C. pneumoniae human genomes (AR39, CWL029, J138 and TW183), providing relatively little insight into strain diversity and evolution of this species.Results: We performed individual gene-by-gene comparisons of the recently sequenced C. pneumoniae koala genome and four C. pneumoniae human genomes to identify species-specific genes, and more importantly, to gain an insight into the genetic diversity and evolution of the species. We selected genes dispersed throughout the chromosome, representing genes that were specific to C. pneumoniae, genes with a demonstrated role in chlamydial biology and/or pathogenicity (n = 49), genes encoding nucleotide salvage or amino acid biosynthesis proteins (n = 6), and extrachromosomal elements (9 plasmid and 2 bacteriophage genes).Conclusions: We have identified strain-specific differences and targets for detection of C. pneumoniae isolates from both human and animal origin. Such characterisation is necessary for an improved understanding of disease transmission and intervention.

Details

Title: Comparison of koala LPCoLN and human strains of Chlamydia pneumoniae highlights extended genetic diversity in the species
Authors: C M Mitchell (Author) - Queensland University of Technology
K M Hovis (Author) - University of Maryland, United States
P M Bavoil (Author) - University of Maryland, United States
G S A Myers (Author) - University of Maryland, United States
J A Carrasco (Author) - University of Maryland, United States
Peter Timms (Author) - Queensland University of Technology
Publication details: BMC Genomics, Vol.11, 442; 10
Publisher: BioMed Central Ltd.
Date published: 2010
DOI: 10.1186/1471-2164-11-442
ISSN: 1471-2164; 1471-2164
Copyright note: Copyright © 2010 Mitchell et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Organisation Unit: University of the Sunshine Coast, Queensland; Centre for Bioinnovation
Language: English
Record Identifier: 99448871302621
Output Type: Journal article
Research Statement: false

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Collaboration types: Domestic collaboration; International collaboration
Web Of Science research areas: Biotechnology & Applied Microbiology; Genetics & Heredity

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