Comparing the effectiveness, safety and tolerability of interventions for depressive symptoms in people with multiple sclerosis: a systematic review and network meta-analysis protocol

Julia Lyons; Stephanie Campese; Yvonne C Learmonth; Alexandra Metse; Allan G Kermode; Amalia Karahalios; Claudia H Marck

doi:10.1136/bmjopen-2021-055796

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Comparing the effectiveness, safety and tolerability of interventions for depressive symptoms in people with multiple sclerosis: a systematic review and network meta-analysis protocol

Journal article

Open access

Peer reviewed

Comparing the effectiveness, safety and tolerability of interventions for depressive symptoms in people with multiple sclerosis: a systematic review and network meta-analysis protocol

Julia Lyons, Stephanie Campese, Yvonne C Learmonth, Alexandra Metse, Allan G Kermode, Amalia Karahalios and Claudia H Marck

BMJ Open, Vol.12, pp.1-7

2022

DOI: https://doi.org/10.1136/bmjopen-2021-055796

PMCID: PMC9185417

PMID: 35680262

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Abstract

Clinical and health psychology

Allied health and rehabilitation science

Psychiatry (incl. psychotherapy)

Mental health

Background: Comorbid depression is prevalent in people with multiple sclerosis (MS). Depression is commonly untreated or undertreated, thus, there is a need for effective and safe interventions and current guidelines recommend psychological and pharmaceutical interventions for people with MS. However, research suggests that other interventions, such as exercise, could also be effective. The comparative efficacy and safety of intervention modalities have not been quantified. We plan to conduct a systematic review and network meta-analysis to compare efficacy and safety of psychological, pharmaceutical, physical and magnetic stimulation interventions for depression in people with MS. Methods: and analysis We will search EMBASE, Medline, Cochrane CENTRAL, APA PsycINFO, Web of Science, CINAHL and PEDro from inception to 31 December 2021. Search terms will stem from three concepts: MS, depression and randomised controlled trials. Included studies will be randomised controlled trials, where participants are people with MS randomised to receive one of the aforementioned intervention types, and depression or depressive symptoms is the primary outcome, only outcome or secondary outcome with an a priori power calculation. Screening, data extraction and risk of bias assessment (using the Risk of Bias 2 tool) will be conducted independently by two reviewers. If possible, we will synthesise the evidence by fitting a frequentist network meta-analysis model with multivariate random effects, or a pairwise random-effects meta-analysis model. For each model, efficacy will be measured using a standardised mean difference, and safety using an OR. We plan to provide summary measures including forest plots, a geometry of the network, surface under the cumulative ranking curve, and a league table, and perform subgroup analyses. Otherwise, a narrative review will be provided. Ethics and dissemination: Ethics is not required for a systematic review and network meta-analysis. Results will be published in a peer reviewed journal. PROSPERO registration number: CRD42020209803.

Details

Title: Comparing the effectiveness, safety and tolerability of interventions for depressive symptoms in people with multiple sclerosis: a systematic review and network meta-analysis protocol
Authors: Julia Lyons (Author) - The University of Melbourne
Stephanie Campese (Author) - The University of Melbourne
Yvonne C Learmonth (Author) - Murdoch University
Alexandra Metse (Author) - University of the Sunshine Coast, Queensland, School of Health and Behavioural Sciences - Legacy
Allan G Kermode (Author) - The University of Western Australia
Amalia Karahalios (Author) - The University of Melbourne
Claudia H Marck (Author) - The University of Melbourne
Publication details: BMJ Open, Vol.12, pp.1-7
Publisher: B M J Group
Date published: 2022
DOI: 10.1136/bmjopen-2021-055796
ISSN: 2044-6055
PMID: 35680262; PMC9185417
Copyright note: © Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/ This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.
Organisation Unit: University of the Sunshine Coast, Queensland; School of Health - Psychology; School of Health and Behavioural Sciences - Legacy
Language: English
Record Identifier: 99645779102621
Output Type: Journal article

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