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Published VersionCC BY-NC V4.0, Open Access
Journal article
Comparing the effectiveness, safety and tolerability of interventions for depressive symptoms in people with multiple sclerosis: a systematic review and network meta-analysis protocol
BMJ Open, Vol.12, pp.1-7
2022
Abstract
Background: Comorbid depression is prevalent in people with multiple sclerosis (MS). Depression is commonly untreated or undertreated, thus, there is a need for effective and safe interventions and current guidelines recommend psychological and pharmaceutical interventions for people with MS. However, research suggests that other interventions, such as exercise, could also be effective. The comparative efficacy and safety of intervention modalities have not been quantified.
We plan to conduct a systematic review and network meta-analysis to compare efficacy and safety of psychological, pharmaceutical, physical and magnetic stimulation interventions for depression in people with MS.
Methods: and analysis We will search EMBASE, Medline, Cochrane CENTRAL, APA PsycINFO, Web of Science, CINAHL and PEDro from inception to 31 December 2021. Search terms will stem from three concepts: MS, depression and randomised controlled trials. Included studies will be randomised controlled trials, where participants are people with MS randomised to receive one of the aforementioned intervention types, and depression or depressive symptoms is the primary outcome, only outcome or secondary outcome with an a priori power calculation. Screening, data extraction and risk of bias assessment (using the Risk of Bias 2 tool) will be conducted independently by two reviewers. If possible, we will synthesise the evidence by fitting a frequentist network meta-analysis model with multivariate random effects, or a pairwise random-effects meta-analysis model. For each model, efficacy will be measured using a standardised mean difference, and safety using an OR. We plan to provide summary measures including forest plots, a geometry of the network, surface under the cumulative ranking curve, and a league table, and perform subgroup analyses. Otherwise, a narrative review will be provided.
Ethics and dissemination: Ethics is not required for a systematic review and network meta-analysis. Results will be published in a peer reviewed journal.
PROSPERO registration number: CRD42020209803.
Details
- Title
- Comparing the effectiveness, safety and tolerability of interventions for depressive symptoms in people with multiple sclerosis: a systematic review and network meta-analysis protocol
- Authors
- Julia Lyons (Author) - The University of MelbourneStephanie Campese (Author) - The University of MelbourneYvonne C Learmonth (Author) - Murdoch UniversityAlexandra Metse (Author) - University of the Sunshine Coast, Queensland, School of Health and Behavioural Sciences - LegacyAllan G Kermode (Author) - The University of Western AustraliaAmalia Karahalios (Author) - The University of MelbourneClaudia H Marck (Author) - The University of Melbourne
- Publication details
- BMJ Open, Vol.12, pp.1-7
- Publisher
- B M J Group
- Date published
- 2022
- DOI
- 10.1136/bmjopen-2021-055796
- ISSN
- 2044-6055
- Copyright note
- © Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/ This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.
- Organisation Unit
- University of the Sunshine Coast, Queensland; School of Health - Psychology; School of Health and Behavioural Sciences - Legacy
- Language
- English
- Record Identifier
- 99645779102621
- Output Type
- Journal article
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