Comparative genomic analysis of human Chlamydia pneumoniae isolates from respiratory, brain and cardiac tissues

Eileen Roulis; Nathan Bachmann; Garry S A Myers; Wilhelmina Huston; James Summersgill; Alan Hudson; Ute Dreses-Werringloer; Adam Polkinghorne; Peter Timms

doi:10.1016/j.ygeno.2015.09.008

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Comparative genomic analysis of human Chlamydia pneumoniae isolates from respiratory, brain and cardiac tissues

Journal article

Peer reviewed

Comparative genomic analysis of human Chlamydia pneumoniae isolates from respiratory, brain and cardiac tissues

Eileen Roulis, Nathan Bachmann, Garry S A Myers, Wilhelmina Huston, James Summersgill, Alan Hudson, Ute Dreses-Werringloer, Adam Polkinghorne and Peter Timms

Genomics, Vol.106(6), pp.373-383

2015

DOI: https://doi.org/10.1016/j.ygeno.2015.09.008

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Abstract

chlamydia pneumoniae

comparative genomics

evolution

recombination

cardiovascular

Alzheimer's disease

Chlamydia pneumoniae is an obligate intracellular bacterium implicated in a wide range of human diseases including atherosclerosis and Alzheimer's disease. Efforts to understand the relationships between C. pneumoniae detected in these diseases have been hindered by the availability of sequence data for non-respiratory strains. In this study, we sequenced the whole genomes for C. pneumoniae isolates from atherosclerosis and Alzheimer's disease, and compared these to previously published C. pneumoniae genomes. Phylogenetic analyses of these new C. pneumoniae strains indicate two sub-groups within human C. pneumoniae, and suggest that both recombination and mutation events have driven the evolution of human C. pneumoniae. Further fine-detailed analyses of these new C. pneumoniae sequences show several genetically variable loci. This suggests that similar strains of C. pneumoniae are found in the brain, lungs and cardiovascular system and that only minor genetic differences may contribute to the adaptation of particular strains in human disease.

Details

Title: Comparative genomic analysis of human Chlamydia pneumoniae isolates from respiratory, brain and cardiac tissues
Authors: Eileen Roulis (Author) - Queensland University of Technology
Nathan Bachmann (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and Engineering
Garry S A Myers (Author) - University of Technology Sydney
Wilhelmina Huston (Author) - Queensland University of Technology
James Summersgill (Author) - University of Louisville, United States
Alan Hudson (Author) - Wayne State University, United States
Ute Dreses-Werringloer (Author) - Wayne State University, United States
Adam Polkinghorne (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and Engineering
Peter Timms (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and Engineering
Publication details: Genomics, Vol.106(6), pp.373-383
Publisher: Academic Press
Date published: 2015
DOI: 10.1016/j.ygeno.2015.09.008
ISSN: 0888-7543
Grants: Specificity of Chlamydia pneumoniae for humans: analysis of previous cross-host transmission events and the role of tryptophan availability in host specificity, 1004666, National Health and Medical Research Council (Australia, Canberra) - NHMRC
Organisation Unit: Centre for Bioinnovation
Language: English
Record Identifier: 99449401102621
Output Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Web Of Science research areas: Biotechnology & Applied Microbiology; Genetics & Heredity

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