Comorbid Externalising Behaviour in AD/HD: Evidence for a Distinct Pathological Entity in Adolescence

S Perera; D Crewther; R Croft; H Keage; Daniel F Hermens; C R Clark

doi:10.1371/journal.pone.0041407

Back

Comorbid Externalising Behaviour in AD/HD: Evidence for a Distinct Pathological Entity in Adolescence

Journal article

Open access

Peer reviewed

Comorbid Externalising Behaviour in AD/HD: Evidence for a Distinct Pathological Entity in Adolescence

S Perera, D Crewther, R Croft, H Keage, Daniel F Hermens and C R Clark

PLoS One, Vol.7(9), e41407

2012

DOI: https://doi.org/10.1371/journal.pone.0041407

Files and links (2)

pdf

PDF - Published Version (Open Access)390.89 kBDownload View

Published VersionPDF - Published Version (Open Access)CC BY V4.0, Open Access

url

https://doi.org/10.1371/journal.pone.0041407View

Published Version

Abstract

adolescents

psychometrics

attention

behaviour

diagnostic medicine

children

While the profiling of subtypes of Attention Deficit Hyperactivity Disorder (AD/HD) have been the subject of considerable scrutiny, both psychometrically and psychophysiologically, little attention has been paid to the effect of diagnoses comorbid with AD/HD on such profiles. This is despite the greater than 80% prevalence of comorbidity under the DSM-IV-TR diagnostic definitions. Here we investigate the event related potential (ERP) and psychometric profiles of Controls, AD/HD, and comorbid AD/HD (particularly AD/HD+ODD/CD) groups on six neurocognitive tasks thought to probe the constructs of selective and sustained attention, response inhibition and executive function. Data from 29 parameters extracted from a child group (age range 6 to 12; 52 Controls and 64 AD/HD) and from an adolescent group (age range 13 to 17; 79 Controls and 88 AD/HD) were reduced via a Principal Components Analysis, the 6 significant eigenvectors then used as determinants of cluster membership via a Two-Step Cluster Analysis. Two clusters were found in the analysis of the adolescent age group - a cluster dominated by Control and AD/HD participants without comorbidity, while the second cluster was dominated by AD/HD participants with externalising comorbidity (largely oppositional defiant/conduct disorder ODD/CD). A similar segregation within the child age group was not found. Further analysis of these objectively determined clusters in terms of their clinical diagnoses indicates a significant effect of ODD/CD comorbidity on a concurrent AD/HD diagnosis. We conclude that comorbid externalising behaviour in AD/HD constitutes a distinct pathological entity in adolescence. © 2012 Perera et al.

Details

Title: Comorbid Externalising Behaviour in AD/HD: Evidence for a Distinct Pathological Entity in Adolescence
Authors: S Perera (Author) - Swinburne University of Technology
D Crewther (Author) - Swinburne University of Technology
R Croft (Author) - University of Wollongong
H Keage (Author) - Flinders University
Daniel F Hermens (Author) - University of Sydney
C R Clark (Author) - Flinders University
Publication details: PLoS One, Vol.7(9), e41407; 12
Publisher: Public Library of Science
Date published: 2012
DOI: 10.1371/journal.pone.0041407
ISSN: 1932-6203
Copyright note: Copyright © Perera et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Organisation Unit: University of the Sunshine Coast, Queensland; Thompson Institute
Language: English
Record Identifier: 99450804102621
Output Type: Journal article

Metrics

8 File views/ downloads

638 Record Views

5 Times Cited - Web of Science

InCites Highlights

These are selected metrics from InCites Benchmarking & Analytics tool, related to this output

Collaboration types: Domestic collaboration
Web Of Science research areas: Psychiatry

UN Sustainable Development Goals (SDGs)

This output has contributed to the advancement of the following goals:

Source: InCites