Cohort profile: the Brain and Mind Centre Optymise cohort: tracking multidimensional outcomes in young people presenting for mental healthcare

Joanne S Carpenter; Frank Iorfino; Shane Cross; Alissa Nichles; Natalia Zmicerevska; Jacob J Crouse; Jake R Palmer; Alexis E Whitton; Django White; Sharon L Naismith; Adam J Guastella; Daniel F Hermens; Jan Scott; Elizabeth M Scott; Ian B Hickie

doi:10.1136/bmjopen-2019-030985

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Cohort profile: the Brain and Mind Centre Optymise cohort: tracking multidimensional outcomes in young people presenting for mental healthcare

Joanne S Carpenter, Frank Iorfino, Shane Cross, Alissa Nichles, Natalia Zmicerevska, Jacob J Crouse, Jake R Palmer, Alexis E Whitton, Django White, Sharon L Naismith, …

BMJ Open, Vol.10(3), pp.1-12

2020

DOI: https://doi.org/10.1136/bmjopen-2019-030985

PMCID: PMC7170572

PMID: 32229519

Appears in Thompson Institute Research Collection

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Abstract

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Purpose: The Brain and Mind Centre (BMC) Optymise cohort assesses multiple clinical and functional domains longitudinally in young people presenting for mental health care and treatment. Longitudinal tracking of this cohort will allow investigation of the relationships between multiple outcome domains across the course of care. Subsets of Optymise have completed detailed neuropsychological and neurobiological assessments, permitting investigation of associations between these measures and longitudinal course. Participants: Young people (aged 12-30) presenting to clinics coordinated by the BMC were recruited to a research register (n=6743) progressively between June 2008 and July 2018. To date, 2767 individuals have been included in Optymise based on the availability of at least one detailed clinical assessment. Measures: Trained researchers use a clinical research proforma to extract key data from clinical files to detail social and occupational functioning, clinical presentation, self-harm and suicidal thoughts and behaviours, alcohol and other substance use, physical health comorbidities, personal and family history of mental illness, and treatment utilisation at the following time points: baseline, 3, 6, 12, 24, 36, 48, and 60 months, and time last seen. Findings to date: There is moderate to substantial agreement between raters for data collected via the proforma. While wide variations in individual illness course are clear, social and occupational outcomes suggest that the majority of cohort members show no improvement in functioning over time. Differential rates of longitudinal transition are reported between early and late stages of illness, with a number of baseline factors associated with these transitions. Furthermore, there are longitudinal associations between prior suicide attempts and inferior clinical and functional outcomes. Future plans: Future reports will detail the longitudinal course of each outcome domain and examine multidirectional relationships between these domains both cross-sectionally and longitudinally, and explore in subsets the associations between detailed neurobiological measures and clinical, social and functional outcomes.

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Title: Cohort profile: the Brain and Mind Centre Optymise cohort: tracking multidimensional outcomes in young people presenting for mental healthcare
Authors: Joanne S Carpenter (Author) - University of Sydney
Frank Iorfino (Author) - University of Sydney
Shane Cross (Author) - University of Sydney
Alissa Nichles (Author) - University of Sydney
Natalia Zmicerevska (Author) - University of Sydney
Jacob J Crouse (Author) - University of Sydney
Jake R Palmer (Author) - University of Sydney
Alexis E Whitton (Author) - University of Sydney
Django White (Author) - University of Sydney
Sharon L Naismith (Author) - University of Sydney
Adam J Guastella (Author) - University of Sydney
Daniel F Hermens (Author) - University of the Sunshine Coast - Thompson Institute
Jan Scott (Author) - University of Sydney
Elizabeth M Scott (Author) - University of Sydney
Ian B Hickie (Author) - University of Sydney
Publication details: BMJ Open, Vol.10(3), pp.1-12
Publisher: B M J Group
Date published: 2020
DOI: 10.1136/bmjopen-2019-030985
ISSN: 2044-6055
PMID: 32229519; PMC7170572
Copyright note: Copyright © Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.
Organisation Unit: University of the Sunshine Coast, Queensland; Thompson Institute
Language: English
Record Identifier: 99450954902621
Output Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Web Of Science research areas: Psychiatry

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