Journal article
Cognitive remediation improves memory and psychosocial functioning in first-episode psychiatric out-patients
Psychological Medicine, Vol.43(6), pp.1161-1173
2013
Abstract
Cognitive remediation (CR) is an effective treatment for several psychiatric disorders. To date, there have been no published studies examining solely first-episode psychiatric cohorts, despite the merits demonstrated by early intervention CR studies. The current study aimed to assess the effectiveness of CR in patients with a first-episode of either major depression or psychosis. Method Fifty-five patients (mean age = 22.8 years, s.d. = 4.3) were randomly assigned to either CR (n = 28) or treatment as usual (TAU; n = 27). CR involved once-weekly 2-h sessions for a total of 10 weeks. Patients were comprehensively assessed before and after treatment. Thirty-six patients completed the study, and analyses were conducted using an intent-to-treat (ITT) approach with all available data. Results In comparison to TAU, CR was associated with improved immediate learning and memory controlling for diagnosis and baseline differences. Similarly, CR patients demonstrated greater improvements than TAU patients in psychosocial functioning irrespective of diagnosis. Delayed learning and memory improvements mediated the effect of treatment on psychosocial functioning at a marginal level. Conclusions CR improves memory and psychosocial outcome in first-episode psychiatric out-patients for both depression and psychosis. Memory potentially mediated the functional gains observed. Future studies need to build on the current findings in larger samples using blinded allocation and should incorporate longitudinal follow-up and assessment of potential moderators (e.g. social cognition, self-efficacy) to examine sustainability and the precise mechanisms of CR effects respectively. © 2012 Cambridge University Press.
Details
- Title
- Cognitive remediation improves memory and psychosocial functioning in first-episode psychiatric out-patients
- Authors
- R S C Lee (Author) - University of SydneyM A Redoblado-Hodge (Author) - The Children's Hospital at WestmeadS L Naismith (Author) - University of SydneyDaniel F Hermens (Author) - University of SydneyM A Porter (Author) - University of SydneyI B Hickie (Author) - University of Sydney
- Publication details
- Psychological Medicine, Vol.43(6), pp.1161-1173
- Publisher
- Cambridge University Press
- Date published
- 2013
- DOI
- 10.1017/S0033291712002127
- ISSN
- 0033-2917
- Copyright note
- Copyright © Cambridge University Press 2012 The online version of this article is published within an Open Access environment subject to the conditions of the Creative Commons Attribution-NonCommercial-ShareAlike licence . The written permission of Cambridge University Press must be obtained for commercial re-use.
- Organisation Unit
- University of the Sunshine Coast, Queensland; Thompson Institute
- Language
- English
- Record Identifier
- 99450586402621
- Output Type
- Journal article
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- Domestic collaboration
- Web Of Science research areas
- Psychiatry
- Psychology
- Psychology, Clinical
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