Journal article
Cognitive generation of affect in hypomania: An fMRI study
Bipolar Disorders, Vol.6(4), pp.271-285
2004
Abstract
Objective: To identify the brain regions associated with the cognitive generation of affect in hypomanic bipolar patients. Methods: The study examined 10 hypomanic female subjects with bipolar affective disorder, and 10 age- and sex-matched comparison subjects using functional magnetic resonance imaging (fMRI) while viewing alternating blocks of captioned-pictures designed to evoke negative, positive or no affective change. The activation paradigm involved the presentation of the same visual materials over three experiments alternating (a) negative and reference, (b) positive and reference and (c) positive and negative captioned-pictures. Results: The stimuli produced activation in both patients and comparison subjects in brain regions previously implicated in the generation and modulation of affect, in particular the prefrontal cortex. Activation in patients involved additional subcortical regions namely the caudate and thalamus. Conclusions: This preliminary study suggests that hypomanic patients recruit additional subcortical limbic systems for emotional evaluation when advanced prefrontal cortical processing is no longer sufficient. The differential patterns of activation inform us about bipolar disorder and may have potential diagnostic and therapeutic significance. © Blackwell Munksgaard, 2004.
Details
- Title
- Cognitive generation of affect in hypomania: An fMRI study
- Authors
- G S Malhi (Author) - University of SydneyJim Lagopoulos (Author) - University of SydneyP Sachdev (Author) - University of SydneyP B Mitchell (Author) - University of SydneyB Ivanovski (Author) - University of SydneyG B Parker (Author) - University of Sydney
- Publication details
- Bipolar Disorders, Vol.6(4), pp.271-285
- Publisher
- Wiley-Blackwell Publishing Inc.
- Date published
- 2004
- DOI
- 10.1111/j.1399-5618.2004.00123.x
- ISSN
- 1398-5647
- Organisation Unit
- University of the Sunshine Coast, Queensland; Thompson Institute
- Language
- English
- Record Identifier
- 99449129402621
- Output Type
- Journal article
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- Domestic collaboration
- Web Of Science research areas
- Clinical Neurology
- Neurosciences
- Psychiatry
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