Cognitive and behavioral abnormalities in individuals with Alzheimer's disease, mild cognitive impairment, and subjective memory complaints

Samuel L. Warren; Edwina Reid; Paige Whitfield; Ahmed M. Helal; Eid G. Abo Hamza; Richard Tindle; Ahmed A. Moustafa; Mohamed S. Hamid

doi:10.1007/s12144-023-04281-1

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Cognitive and behavioral abnormalities in individuals with Alzheimer's disease, mild cognitive impairment, and subjective memory complaints

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Cognitive and behavioral abnormalities in individuals with Alzheimer's disease, mild cognitive impairment, and subjective memory complaints

Samuel L. Warren, Edwina Reid, Paige Whitfield, Ahmed M. Helal, Eid G. Abo Hamza, Richard Tindle, Ahmed A. Moustafa and Mohamed S. Hamid

Current Psychology, Vol.43, pp.800-810

2024

DOI: https://doi.org/10.1007/s12144-023-04281-1

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Abstract

Alzheimer s disease (AD)

Mild cognitive impairment (MCI)

Subjective memory complaints (SMC)

Episodic memory

UniSC Diversity Area - Disability and Inclusion

In this study, we investigated the ability of commonly used neuropsychological tests to detect cognitive and functional decline across the Alzheimer's disease (AD) continuum. Moreover, as preclinical AD is a key area of investigation, we focused on the ability of neuropsychological tests to distinguish the early stages of the disease, such as individuals with Subjective Memory Complaints (SMC). This study included 595 participants from the Alzheimer's Disease Neuroimaging Initiative (ADNI) dataset who were cognitively normal (CN), SMC, mild cognitive impairment (MCI; early or late stage), or AD. Our cognitive measures included the Rey Auditory Verbal Learning Test (RAVLT), the Everyday Cognition Questionnaire (ECog), the Functional Abilities Questionnaire (FAQ), the Alzheimer's Disease Assessment Scale Cognitive Subscale (ADAS-Cog), the Montreal Cognitive Assessment scale (MoCA), and the Trail Making test (TMT-B). Overall, our results indicated that the ADAS13, RAVLT (learning), FAQ, ECog, and MoCA were all predictive of the AD progression continuum. However, TMTB and the RAVLT (immediate and forgetting) were not significant predictors of the AD continuum. Indeed, contrary to our expectations ECog self report (partner and patient) were the two strongest predictors in the model to detect the progression from CN to AD. Accordingly, we suggest using the ECog (both versions), RAVLT (learning), ADAS13, and the MoCA to screen all stages of the AD continuum. In conclusion, we infer that these tests could help clinicians effectively detect the early stages of the disease (e.g., SMC) and distinguish the different stages of AD.

Details

Title: Cognitive and behavioral abnormalities in individuals with Alzheimer's disease, mild cognitive impairment, and subjective memory complaints
Authors: Samuel L. Warren (Author) - Bond University
Edwina Reid (Author) - Western Sydney University
Paige Whitfield (Author) - Western Sydney University
Ahmed M. Helal (Author) - Tanta University
Eid G. Abo Hamza (Author) - Tanta University
Richard Tindle (Author) - University of the Sunshine Coast, Queensland, School of Health - Psychology
Ahmed A. Moustafa (Corresponding Author) - Bond University
Mohamed S. Hamid (Author) - Ain Shams University
Publication details: Current Psychology, Vol.43, pp.800-810
Publisher: Springer New York LLC
Date published: 2024
DOI: 10.1007/s12144-023-04281-1
ISSN: 1046-1310
Copyright note: This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
Grant note: Australian Governments Research Training Program Scholarship
Organisation Unit: University of the Sunshine Coast, Queensland; School of Health - Psychology
Language: English
Record Identifier: 99714698702621
Output Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Web Of Science research areas: Psychology, Multidisciplinary

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