Journal article
Cognitive Fitness to Drive in Huntington’s Disease: Assessing the Clinical Utility of DriveSafe DriveAware
Journal of Huntington's Disease, Vol.8(1), pp.87-95
2019
Abstract
Background: DriveSafe DriveAware (DSDA) has been validated as an off-road screening tool for predicting on-road driving performance in clinical populations, but its utility in people with Huntington’s disease (HD) is unknown. Objective:Our aim was to evaluate the utility of DSDA in people with HD by demonstrating sensitivity of DSDA scores to HD progression and exploring associations between DSDA performance and cognitive functions that are essential to driving and impaired in people with HD. Methods: We administered the iPad application version of DSDA to 26 pre-symptomatic and symptomatic participants with HD. Disease progression was assessed via measures of motor impairment, disease burden and functional capacity. Standardised neuropsychological tests were used to assess cognitive function across several domains including attention, processing speed, planning, and visuoperception. Results: Results underscore the sensitivity of DSDA to HD progression and cognitive impairment; that is, poorer DSDA performance was associated with greater HD severity and poorer cognitive ability across the domains of attention, processing speed, and planning. Nevertheless, we identified a proportion of participants with HD who were predicted to pass on-road testing based on DSDA, but scored in the impaired range on multiple cognitive tests. These participants tended to score closer to the cut-off score used by DSDA to categorise pass/fail outcomes. Conclusions: Our findings demonstrate potential for use of DSDA in the HD population, however, significant variability in cognitive performance among those predicted to ‘pass’ on-road driving assessment suggests the screening tool requires further development for use with HD drivers.
Details
- Title
- Cognitive Fitness to Drive in Huntington’s Disease: Assessing the Clinical Utility of DriveSafe DriveAware
- Authors
- Hayden J. Farrell (Author) - School of Psychological Sciences, and, Institute of Cognitive and Clinical Neurosciences, Faculty of Medicine, Nursing and Health Sciences, Monash University, Clayton, VIC, AustraliaSophie C. Andrews (Author) - Monash UniversityNicholas P. Ryan (Author) - Deakin UniversityMarie-Claire Davis (Author) - Calvary Health Care BethlehemStephanie Gordon (Author) - School of Psychological Sciences, and, Institute of Cognitive and Clinical Neurosciences, Faculty of Medicine, Nursing and Health Sciences, Monash University, Clayton, VIC, AustraliaJulie C. Stout (Author) - Australian Regenerative Medicine InstituteFiona Fisher (Author) - Calvary Health Care Bethlehem
- Publication details
- Journal of Huntington's Disease, Vol.8(1), pp.87-95
- Publisher
- IOS Press
- DOI
- 10.3233/JHD-180323
- ISSN
- 1879-6400
- Organisation Unit
- University of the Sunshine Coast, Queensland; Thompson Institute
- Language
- English
- Record Identifier
- 99659597202621
- Output Type
- Journal article
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