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Journal article
Coexisiting type 1 diabetes and celiac disease is associated with lower Hba1c when compared to type 1 diabetes alone: data from the Australasian Diabetes Data Network (ADDN) registry
Acta Diabetologica, Vol.60, pp.1471-1477
2023
PMID: 37338603
Abstract
Aim: To compare HbA1c and clinical outcomes in adolescents and young adults with type 1 diabetes (T1D), with or without celiac disease (CD).
Methods: Longitudinal data were extracted from ADDN, a prospective clinical diabetes registry. Inclusion criteria were T1D (with or without CD), ≥ 1 HbA1c measurement, age 16-25 years and diabetes duration ≥ 1 year at last measurement. Multivariable Generalised Estimated Equation models were used for longitudinal analysis of variables associated with HbA1c.
Results: Across all measurements, those with coexisting T1D and CD had lower HbA1c when compared to those with T1D alone (8.5 ± 1.5% (69.4 ± 16.8 mmol/mol) vs. 8.7 ± 1.8% (71.4 ± 19.8 mmol/mol); p < 0.001); lower HbA1c was associated with shorter diabetes duration (B = - 0.06; 95% CI - 0.07 to - 0.05; p < 0.001), male sex (B = - 0.24; - 0.36 to - 0.11; p < 0.001), insulin pump therapy use (B = - 0.46; -0.58 to -0.34; p < 0.001), coexistence of T1D and CD (B = - 0.48 to - 0.07; p = 0.01), blood pressure (B = - 0.16; - 0.23 to - 0.09; p < 0.001) and body mass index (B = -0.03; - 0.02 to - 0.04; p = 0.01) in the normal range. At last measurement, 11.7% of the total population had a HbA1c < 7.0% (53.0 mmol/mol).
Conclusions: Across all measurements, coexisting T1D and CD is associated with lower HbA1c when compared to T1D alone. However, HbA1c is above target in both groups.
Details
- Title
- Coexisiting type 1 diabetes and celiac disease is associated with lower Hba1c when compared to type 1 diabetes alone: data from the Australasian Diabetes Data Network (ADDN) registry
- Authors
- Steven James (Corresponding Author) - University of the Sunshine Coast, Queensland, School of Health - NursingLin Perry (Author) - University of Technology SydneyJulia Lowe (Author) - University of TorontoKim Donaghue (Author) - Children's Hospital at WestmeadAnna Pham Short (Author) - Children's Hospital at WestmeadMaria E Craig (Author) - Children's Hospital at WestmeadADDN Study Group (Author)
- Publication details
- Acta Diabetologica, Vol.60, pp.1471-1477
- Publisher
- Springer Milano
- Date published
- 2023
- DOI
- 10.1007/s00592-023-02113-z
- ISSN
- 1432-5233; 0940-5429
- PMID
- 37338603
- Copyright note
- This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
- Grant note
- APP1136735/ NHMRC
- Organisation Unit
- School of Health - Nursing; University of the Sunshine Coast, Queensland
- Language
- English
- Record Identifier
- 99735295102621
- Output Type
- Journal article
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