Clonal dissemination of methicillin-resistant Staphylococcus aureus in patients and the hospital environment

S Javidnia; M Talebi; M Saifi; Mohammad Katouli; A R Lari; M R Pourshafie

doi:10.1016/j.ijid.2013.01.032

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Clonal dissemination of methicillin-resistant Staphylococcus aureus in patients and the hospital environment

Journal article

Peer reviewed

Clonal dissemination of methicillin-resistant Staphylococcus aureus in patients and the hospital environment

S Javidnia, M Talebi, M Saifi, Mohammad Katouli, A R Lari and M R Pourshafie

International Journal of Infectious Diseases, Vol.17(9), pp.e691-e695

2013

DOI: https://doi.org/10.1016/j.ijid.2013.01.032

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Abstract

MRSA

nosocomial infection

PFGE

PhPlate

antibiotic resistance

Background: Methicillin is the drug of choice to treat infections caused by resistant strains of Staphylococcus aureus. However, methicillin-resistant S. aureus (MRSA) is now becoming endemic in many hospitals worldwide and is the cause of nosocomial outbreaks. Methods: To assess clonality and dissemination of MRSA strains in the hospitals of Tehran, a total of 60 MRSA strains were isolated from hospitalized patients (n = 44) and hospital equipment and environment (n = 16) of three metropolitan hospitals in Tehran between July 2009 and March 2010. These strains were subjected to antimicrobial susceptibility testing, pulsed-field gel electrophoresis (PFGE), and biochemical fingerprinting using the PhPlate system. Results: Results showed the presence of between one and three dominant clonal groups within each hospital, with most equipment and environmental strains being identical to the dominant clones of hospitalized patient strains. The rate of resistance of these strains to the 13 antibiotics tested ranging from 2% to 100%, with resistance being highest for penicillin, ciprofloxacin, and tetracycline (>98% of the isolates). Comparison of the strains isolated from the three hospitals using a combination of PFGE and PhP types showed the presence of 11 clonal groups of MRSA among these hospitals; of these, three common clonal groups also had identical antibiotic resistance patterns and were found in more than one hospital. Conclusions: These data suggest dissemination of a few dominant clonal groups of MRSA strains in hospitals in Tehran, with high level resistance to other commonly used antibiotics.

Details

Title: Clonal dissemination of methicillin-resistant Staphylococcus aureus in patients and the hospital environment
Authors: S Javidnia (Author) - Tehran University of Medical Sciences, Iran
M Talebi (Author) - Tehran University of Medical Sciences, Iran
M Saifi (Author) - Pasteur Institute of Iran, Iran
Mohammad Katouli (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and Engineering
A R Lari (Author) - Tehran University of Medical Sciences, Iran
M R Pourshafie (Author) - Pasteur Institute of Iran, Iran
Publication details: International Journal of Infectious Diseases, Vol.17(9), pp.e691-e695
Publisher: Elsevier Ltd.
Date published: 2013
DOI: 10.1016/j.ijid.2013.01.032
ISSN: 1201-9712
Organisation Unit: University of the Sunshine Coast, Queensland; School of Health and Sport Sciences - Legacy; School of Science, Technology and Engineering; Centre for Bioinnovation
Language: English
Record Identifier: 99448634102621
Output Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Web Of Science research areas: Infectious Diseases

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