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Clinically proven drug targets differentially expressed in the prefrontal cortex of schizophrenia patients276.74 kB
Accepted VersionCC BY-NC-ND V4.0, Open Access
Journal article
Clinically proven drug targets differentially expressed in the prefrontal cortex of schizophrenia patients
Brain, Behavior, and Immunity, Vol.61, pp.259-265
2017
PMID: 27940260
Abstract
Background:
Due to the heterogeneous nature of schizophrenia, understanding the genetic risk for the disease is a complex task. Gene expression studies have proven to be more reliable than association studies as they are consistently replicated in a tissue specific manner.
Methods:
Using RNA-Seq we analysed gene expression in the frontal cortex of 24 individuals with schizophrenia and 25 unaffected controls.
Results:
We identified 1146 genes that were differentially expressed in schizophrenia, approximately 60% of which were up-regulated and 366 of 1146 (32%) also have aberrant DNA methylation (p = 2.46 × 10−39). The differentially expressed genes were significantly overrepresented in several pathways including inflammatory (p = 8.7 × 10−3) and nitric oxide pathways (p = 9.2 × 10−4). Moreover, these genes were significantly enriched for those with a druggable genome (p = 0.04). We identified a number of genes that are significantly up-regulated in schizophrenia as confirmed in other gene expression studies using different brain tissues. Of the 349 genes associated with schizophrenia from the Psychiatric Genomics Consortium we identified 16 genes that are significant from our list of differentially expressed genes.
Conclusions:
Our results identified biological functional genes that are differentially expressed in schizophrenia. A subset of these genes are clinically proven drug targets. We also found a strong pattern of differentially expressed immune response genes that may reflect an underlying defect in schizophrenia.
Details
- Title
- Clinically proven drug targets differentially expressed in the prefrontal cortex of schizophrenia patients
- Authors
- Joanne Voisey (Author) - Queensland University of TechnologyDivya Mehta (Author) - Queensland University of TechnologyRobert McLeay (Author) - Queensland University of TechnologyCharles P Morris (Author) - Queensland University of TechnologyLeesa F Wockner (Author) - QIMR Berghofer Medical Research InstituteErnest P Noble (Author) - University of California Los AngelesBruce R Lawford (Author) - Queensland University of TechnologyRoss Young (Author) - Queensland University of Technology
- Publication details
- Brain, Behavior, and Immunity, Vol.61, pp.259-265
- Publisher
- Elsevier Inc.
- Date published
- 2017
- DOI
- 10.1016/j.bbi.2016.12.006
- ISSN
- 1090-2139; 0889-1591
- PMID
- 27940260
- Copyright note
- Copyright © 2017. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
- Organisation Unit
- University of the Sunshine Coast, Queensland; Office of the Deputy Vice-Chancellor (Research and Innovation)
- Language
- English
- Record Identifier
- 99551003502621
- Output Type
- Journal article
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web Of Science research areas
- Immunology
- Neurosciences
- Psychiatry
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