Clinical utility of distributed source modelling of interictal scalp EEG in focal epilepsy

C Plummer; M Wagner; M Fuchs; S Vogrin; Lucas Litewka; S Farish; C Bailey; A S Harvey; M J Cook

doi:10.1016/j.clinph.2010.04.002

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Clinical utility of distributed source modelling of interictal scalp EEG in focal epilepsy

Journal article

Peer reviewed

Clinical utility of distributed source modelling of interictal scalp EEG in focal epilepsy

C Plummer, M Wagner, M Fuchs, S Vogrin, Lucas Litewka, S Farish, C Bailey, A S Harvey and M J Cook

Clinical Neurophysiology, Vol.121(10), pp.1726-1739

2010

DOI: https://doi.org/10.1016/j.clinph.2010.04.002

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Abstract

EEG source localization

distributed modelling

dipole

BFEC

MTLE

focal epilepsy

Objective: Assess the clinical utility of non-invasive distributed EEG source modelling in focal epilepsy. Methods: Interictal epileptiform discharges were recorded from eight patients - benign focal epilepsy of childhood (BFEC), four; mesial temporal lobe epilepsy (MTLE), four. EEG source localization (ESL) applied 48 forward-inverse-subspace set-ups: forward - standardized, leadfield-interpolated boundary element methods (BEMs, BEMi), finite element method (FEMi); inverse - minimum norm (MNLS), L1 norm (L1), low resolution electromagnetic tomography (LORETA), standardized LORETA (sLORETA); subspace - whole volume (3D), cortex with rotating sources (CxR), cortex with fixed sources (CxN), cortex with fixed extended sources (patch). Current density reconstruction (CDR) maxima defined 'best-fit'. Results: From 19,200 CDR parameter results and 2304 CDR maps, the dominant variables on best-fit were inverse model and subspace constraint. The most clinically meaningful and statistically robust results came with sLORETA-CxR/patch (lower Rolandic in BFEC, basal temporal lobe in MTLE). Computation time was inverse model dependent: sub-second (MNLS, sLORETA), seconds (L1), minutes (LORETA). Conclusions: From the largest number of distributed ESL approaches compared in a clinical setting, an optimum modelling set-up for BFEC and MTLE incorporated sLORETA (inverse), CxR or patch (subspace), and either BEM or FEMi (forward). Computation is efficient and CDR results are reproducible. Significance: Distributed source modelling demonstrates clinical utility for the routine work-up of unilateral BFEC of the typical Rolandic variety, and unilateral MTLE secondary to hippocampal sclerosis. © 2010 International Federation of Clinical Neurophysiology.

Details

Title: Clinical utility of distributed source modelling of interictal scalp EEG in focal epilepsy
Authors: C Plummer (Author) - St. Vincent's Hospital Melbourne
M Wagner (Author) - Compudmedics Neuroscan, Germany
M Fuchs (Author) - St. Vincent's Hospital Melbourne
S Vogrin (Author) - St. Vincent's Hospital Melbourne
Lucas Litewka (Author) - St. Vincent's Hospital Melbourne
S Farish (Author) - University of Melbourne
C Bailey (Author) - Royal Children's Hospital
A S Harvey (Author) - University of Melbourne
M J Cook (Author) - St. Vincent's Hospital Melbourne
Publication details: Clinical Neurophysiology, Vol.121(10), pp.1726-1739
Publisher: Elsevier Ireland Ltd.
DOI: 10.1016/j.clinph.2010.04.002
ISSN: 1388-2457
Organisation Unit: University of the Sunshine Coast, Queensland; UniSC Clinical Trials Centre
Language: English
Record Identifier: 99450075702621
Output Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Web Of Science research areas: Clinical Neurology; Neurosciences

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