Clinical outcomes of vitamin D deficiency and supplementation in cancer patients

L Teleni; J Baker; B Koczwara; Michael G Kimlin; E Walpole; K Tsai; E A Isenring

doi:10.1111/nure.12047

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Clinical outcomes of vitamin D deficiency and supplementation in cancer patients

Journal article

Peer reviewed

Clinical outcomes of vitamin D deficiency and supplementation in cancer patients

L Teleni, J Baker, B Koczwara, Michael G Kimlin, E Walpole, K Tsai and E A Isenring

Nutrition Reviews, Vol.71(9), pp.611-621

2013

DOI: https://doi.org/10.1111/nure.12047

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Abstract

25-hydroxyvitamin D

cancer

cancer-specific outcomes

cholecalciferol

vitamin D deficiency

Results of recent studies suggest that circulating levels of vitamin D may play an important role in cancer-specific outcomes. The present systematic review was undertaken to determine the prevalence of vitamin D deficiency (<25nmol/L) and insufficiency (25-50nmol/L) in cancer patients and to evaluate the association between circulating calcidiol (the indicator of vitamin D status) and clinical outcomes. A systematic search of original, peer-reviewed studies on calcidiol at cancer diagnosis, and throughout treatment and survival, was conducted yielding 4,706 studies. A total of 37 studies met the inclusion criteria for this review. Reported mean blood calcidiol levels ranged from 24.7 to 87.4nmol/L, with up to 31% of patients identified as deficient and 67% as insufficient. The efficacy of cholecalciferol supplementation for raising the concentration of circulating calcidiol is unclear; standard supplement regimens of <1,000IU D3/day may not be sufficient to maintain adequate concentrations or prevent decreasing calcidiol. Dose-response studies linking vitamin D status to musculoskeletal and survival outcomes in cancer patients are lacking. © 2013 International Life Sciences Institute.

Details

Title: Clinical outcomes of vitamin D deficiency and supplementation in cancer patients
Authors: L Teleni (Author) - Queensland University of Technology
J Baker (Author) - University of Queensland
B Koczwara (Author) - Flinders Medical Centre
Michael G Kimlin (Author) - Queensland University of Technology
E Walpole (Author) - Princess Alexandra Hospital
K Tsai (Author) - University of Queensland
E A Isenring (Author) - University of Queensland
Publication details: Nutrition Reviews, Vol.71(9), pp.611-621
Publisher: Oxford University Press
Date published: 2013
DOI: 10.1111/nure.12047
ISSN: 0029-6643
Organisation Unit: University of the Sunshine Coast, Queensland; School of Health and Sport Sciences - Legacy
Language: English
Record Identifier: 99449119202621
Output Type: Journal article

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