Journal article
Clinical, neurocognitive, and demographic factors associated with functional impairment in the Australian Brain and Mind Youth Cohort Study (2008-2016)
BMJ Open, Vol.8(12), e022659
2018
Appears in Thompson Institute Research Collection
Abstract
OBJECTIVES: We sought to determine the unique and shared contributions of clinical, neurocognitive and demographic factors to functional impairment in a large, transdiagnostic, clinical cohort of adolescents and young adults. DESIGN: Cross-sectional baseline data from a prospective, cohort study. SETTING: Help-seeking youth referred from outpatient services were recruited to the Brain and Mind Youth Cohort (2008-2016) in Sydney, Australia. PARTICIPANTS: In total, 1003 outpatients were recruited, aged between 12 and 36 years (mean= 20.4 years, 54% female), with baseline diagnoses of affective, psychotic, developmental or behavioural disorders. INTERVENTIONS: Treatment as usual. PRIMARY OUTCOME MEASURES: Social and occupational functioning was used to index level of functional impairment. Structural equation modelling was used to examine associations between neurocognition, core clinical symptoms and alcohol and substance use, and clinician-rated and researcher-rated functional impairment. Moderator analyses were conducted to determine the potential influence of demographic and clinical factors (eg, medication exposure). RESULTS: Independent of diagnosis, we found that neurocognitive impairments, and depressive, anxiety and negative symptoms, were significantly associated with functioning. The association of neurocognition with social and occupational functioning remained significant even when constraining for age (15-25-year-olds only) or diagnosis (affective disorders only) in the final model. CONCLUSIONS: This study demonstrated that, in a clinically representative sample of youth, the key determinants of functioning may not be disorder specific. Further, evidence of neurocognitive dysfunction suggests that interventions that target cognition and functioning should not necessarily be reserved just for older adults with established illness.
Details
- Title
- Clinical, neurocognitive, and demographic factors associated with functional impairment in the Australian Brain and Mind Youth Cohort Study (2008-2016)
- Authors
- R S C Lee (Author) - University of SydneyDaniel F Hermens (Author) - University of SydneyS L Naismith (Author) - University of SydneyM Kaur (Author) - University of SydneyA J Guastella (Author) - University of SydneyN Glozier (Author) - University of SydneyJan Scott (Author) - Institute of Psychiatry, Psychology and Neuroscience, United KingdomE M Scott (Author) - University of SydneyI B Hickie (Author) - University of Sydney
- Publication details
- BMJ Open, Vol.8(12), e022659
- Publisher
- B M J Group
- Date published
- 2018
- DOI
- 10.1136/bmjopen-2018-022659
- ISSN
- 2044-6055
- Copyright note
- Copyright © 2018 The Author. This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.
- Organisation Unit
- University of the Sunshine Coast, Queensland; Thompson Institute
- Language
- English
- Record Identifier
- 99451210502621
- Output Type
- Journal article
Metrics
7 File views/ downloads
2758 Record Views
InCites Highlights
These are selected metrics from InCites Benchmarking & Analytics tool, related to this output
- Collaboration types
- Domestic collaboration
- International collaboration
- Web Of Science research areas
- Psychiatry
UN Sustainable Development Goals (SDGs)
This output has contributed to the advancement of the following goals:
Source: InCites