Journal article
Clinical comparison of five anti-chlamydial antibiotics in koalas (Phascolarctos cinereus)
PLoS One, Vol.15(7), pp.1-15
2020
Abstract
Chlamydiosis is the most significant infectious disease of koalas (Phascolarctos cinereus). It is primarily a systemic sexually transmitted disease caused by Chlamydia pecorum and was responsible for 46% of the 2348 koala admissions to Australia Zoo Wildlife Hospital between 2013 and 2017. Treatment of chlamydiosis in koalas is complicated by three major factors. Firstly, koalas rely on bacterial fermentation of their high fibre diet making antibiotic therapy a risk. Secondly, they possess efficient metabolic pathways for the excretion of plant toxins and potentially of therapeutic agents. Thirdly, wild koalas, often present to rehabilitation facilities with chronic and severe disease. Traditional anti-chlamydial antibiotics used in other species may cause fatal dysbiosis in koalas or be excreted before they can be effective. We compared five anti-chlamydial antibiotics, azithromycin, chloramphenicol, doxycycline, enrofloxacin and florfenicol, which were used to treat 86 wild koalas with chla-mydiosis presented to Australia Zoo Wildlife Hospital under consistent conditions of nutrition , housing, husbandry and climate. Response to treatment was assessed by recovery from clinical signs, and clearance of detectable Chlamydia via quantitative PCR. Doxycy-cline was the most effective anti-chlamydial antibiotic of the five, producing a 97% cure rate, followed by chloramphenicol (81%), enrofloxacin (75%), florfenicol (66%) and azithromycin (25%). The long-acting injectable preparation of doxycycline was well tolerated by koalas when administered via the subcutaneous route, and the weekly dosing requirement is a major advantage when treating wild animals. These findings indicate that doxycycline is the current drug of choice for the treatment of chlamydiosis in koalas, with chloramphenicol being the best alternative.
Details
- Title
- Clinical comparison of five anti-chlamydial antibiotics in koalas (Phascolarctos cinereus)
- Authors
- Rosemary Booth (Author) - Australia Zoo Wildlife Hospital (Australia)Sharon Nyari (Author) - University of the Sunshine Coast, Queensland, GeneCology Research Centre - Legacy
- Publication details
- PLoS One, Vol.15(7), pp.1-15
- Publisher
- Public Library of Science
- Date published
- 2020
- DOI
- 10.1371/journal.pone.0236758
- ISSN
- 1932-6203
- Copyright note
- Copyright: © 2020 Booth, Nyari. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
- Grant note
- This work was supported by an Australia Research Council Linkage program received by PT. SN received a USC PhD scholarship.
- Organisation Unit
- University of the Sunshine Coast, Queensland; School of Science, Technology and Engineering; Centre for Bioinnovation
- Language
- English
- Record Identifier
- 99469107602621
- Output Type
- Journal article
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