Clinical and cognitive correlates of structural hippocampal change in "at-risk" older adults

E L Elcombe; Jim Lagopoulos; L Mowszowski; K Diamond; M Paradise; I B Hickie; S J G Lewis; S L Naismith

doi:10.1177/0891988713509137

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Clinical and cognitive correlates of structural hippocampal change in "at-risk" older adults

Journal article

Peer reviewed

Clinical and cognitive correlates of structural hippocampal change in "at-risk" older adults

E L Elcombe, Jim Lagopoulos, L Mowszowski, K Diamond, M Paradise, I B Hickie, S J G Lewis and S L Naismith

Journal of Geriatric Psychiatry and Neurology, Vol.27(2), pp.67-76

2014

DOI: https://doi.org/10.1177/0891988713509137

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Abstract

With estimates of dementia expected to rise over the coming decades, there is interest in understanding the factors associated with promoting neuroprotection and limiting neurodegeneration. In this study, we examined the change in the volume of the hippocampus over a 2-month period in 34 older people "at risk" of cognitive decline (mean age = 66.8 years, 38% male). Factors that were examined included cognitive reserve, neuropsychological functioning, depression as well as a lifestyle (cognitive training) intervention. The results showed that over a 2-month period, increases in hippocampal size were associated with having higher premorbid intellect, greater occupational attainment, superior memory, and higher levels of functioning. Conversely, depression and disability were associated with decreases in hippocampal volume. Cognitive training was not associated with changes in hippocampal volume. These findings suggest that factors associated with cognitive reserve, cognition and depression may play an integral pathophysiological role in determining hippocampal volumes in "at-risk" older adults. © The Author(s) 2013.

Details

Title: Clinical and cognitive correlates of structural hippocampal change in "at-risk" older adults
Authors: E L Elcombe (Author) - University of Sydney
Jim Lagopoulos (Author) - University of Sydney
L Mowszowski (Author) - University of Sydney
K Diamond (Author) - University of Sydney
M Paradise (Author) - University of Sydney
I B Hickie (Author) - University of Sydney
S J G Lewis (Author) - University of Sydney
S L Naismith (Author) - University of Sydney
Publication details: Journal of Geriatric Psychiatry and Neurology, Vol.27(2), pp.67-76
Publisher: Sage Publications Inc.
Date published: 2014
DOI: 10.1177/0891988713509137
ISSN: 0891-9887
Organisation Unit: University of the Sunshine Coast, Queensland; Thompson Institute
Language: English
Record Identifier: 99449122902621
Output Type: Journal article

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