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Published VersionCC BY-NC-ND V4.0, Open Access
Journal article
Clinical Evaluations of Macular Structure-Function ConcordanceWith andWithout Drasdo Displacement
Translational Vision Science & Technology, Vol.11(4), pp.1-14
2022
PMID: 35438719
Abstract
Purpose: The purpose of this study was to compare concordance between ganglion cell-inner plexiform layer (GCIPL) data from the Cirrus optical coherence tomographer (OCT) Ganglion Cell Analysis (GCA) and visual fields (VFs), with and without Drasdo displacement.
Methods: From 296 open-angle glaucoma participants, GCIPL deviation and raw thickness data were extracted over locations per the 10-2 VF test grid, with and without application of Drasdo displacement, with global and eccentricity-dependent sensitivities and specificities calculated for both. With OCT and VF data classified as within or outside normative limits, pattern deviation values were compared using paired t-tests and Spearman correlations. Regression models were applied to pattern deviation values as a function of GCIPL thickness, and differences in model performance with and without displacement were compared using extra sums-of-squares F tests.
Results: There were small but significant improvements in global specificity without displacement (0.58–0.59 with displacement and 0.61 without displacement), without notable differences in sensitivity (0.77–0.78 with displacement and 0.76–0.78 without displacement). At abnormal VF locations and without displacement, a higher proportion of correct OCT classifications (P = 0.0008) and significant correlation with worsening pattern deviation values were observed (r = 0.50, P = 0.002). Regression models indicated significantly steeper slopes with Drasdo displacement centrally (P = 0.002–0.04).
Conclusions: With GCA deviation maps, small improvements in structure-function concordance were observed without displacement, which are unlikely to be clinically meaningful. Using GCIPL thickness data, significantly better structure-function concordance was observed centrally with Drasdo displacement.
Translational Relevance: Applying Drasdo displacement on probability-based reports is unlikely to alter clinical impressions of structure-function concordance, but applying displacement with GCIPL thickness data may improve detection of structure-function concordance.
Details
- Title
- Clinical Evaluations of Macular Structure-Function ConcordanceWith andWithout Drasdo Displacement
- Authors
- Janelle Tong (Author) - UNSW SydneyJack Phu (Author) - UNSW SydneyDavid Alonso-Caneiro (Author) - Queensland University of TechnologySieu K. Khuu (Author) - UNSW SydneyMichael Kalloniatis (Corresponding Author) - UNSW Sydney
- Publication details
- Translational Vision Science & Technology, Vol.11(4), pp.1-14
- Publisher
- Association for Research in Vision and Ophthalmology
- Date published
- 2022
- DOI
- 10.1167/tvst.11.4.18
- ISSN
- 2164-2591
- PMID
- 35438719
- Copyright note
- This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
- Grant note
- NHMRC 1186915
- Organisation Unit
- School of Science, Technology and Engineering
- Language
- English
- Record Identifier
- 99973593102621
- Output Type
- Journal article
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