Circulating trace elements for the prediction of preeclampsia and small for gestational age babies

Daniel R. McKeating; Joshua J. Fisher; Teresa MacDonald; Sue Walker; Stephen Tong; William W. Bennett; Tu’uhevaha J. Kaitu’u-Lino; Anthony V. Perkins

doi:10.1007/s11306-021-01840-0

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Circulating trace elements for the prediction of preeclampsia and small for gestational age babies

Journal article

Peer reviewed

Circulating trace elements for the prediction of preeclampsia and small for gestational age babies

Daniel R. McKeating, Joshua J. Fisher, Teresa MacDonald, Sue Walker, Stephen Tong, William W. Bennett, Tu’uhevaha J. Kaitu’u-Lino and Anthony V. Perkins

Metabolomics, Vol.17, pp.1-11

2021

DOI: https://doi.org/10.1007/s11306-021-01840-0

PMID: 34557980

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Abstract

trace elements

pregnancy

preeclampsia

small for genstational age

Introduction: Poor gestational outcomes due to placental insufficiency can have lifelong consequences for mother and child. Objective: There is a need for better methods of diagnosis, and elemental metabolomics may provide a means to determine the risk of gestational disorders. Methods: This study used blood plasma samples collected at 36 weeks’ gestation from women who later developed preeclampsia (n = 38), or small-for-gestational age babies (n = 91), along with matched controls (n = 193). Multi-element analysis was conducted by inductively coupled plasma mass spectrometer (ICP-MS), allowing simultaneous measurement of 28 elements. Results: Women who later developed PE, exhibited significantly increased concentrations of K, Rb and Ba. For SGA pregnancies, there was a significant increase in Cu and a decrease in As concentrations. Despite significant differences in single elements, the elemental profile of groups indicated no clustering of control, PE, or SGA samples. Positive predicative values correctly identified approximately 60% of SGA and 70% of PE samples. Conclusion: This is the first-time elemental metabolomics has been used to predict SGA and PE at 36 weeks. Though significant changes were identified, routine clinical use may be limited but may contribute to a multi marker test. Future analysis should include other biomarkers, metabolic data or clinical measurements made throughout gestation.

Details

Title: Circulating trace elements for the prediction of preeclampsia and small for gestational age babies
Authors: Daniel R. McKeating (Author) - Griffith University
Joshua J. Fisher (Author) - University of Newcastle Australia
Teresa MacDonald (Author) - Mercy Hospital for Women
Sue Walker (Author) - Mercy Hospital for Women
Stephen Tong (Author) - Mercy Hospital for Women
William W. Bennett (Author) - Griffith University
Tu’uhevaha J. Kaitu’u-Lino (Author) - Mercy Hospital for Women
Anthony V. Perkins (Corresponding Author) - Griffith University
Publication details: Metabolomics, Vol.17, pp.1-11
Publisher: Springer New York LLC
DOI: 10.1007/s11306-021-01840-0
ISSN: 1573-3890
PMID: 34557980
Organisation Unit: University of the Sunshine Coast, Queensland; School of Health and Behavioural Sciences - Legacy; School of Health
Language: English
Record Identifier: 99685194802621
Output Type: Journal article

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Collaboration types: Domestic collaboration
Web Of Science research areas: Endocrinology & Metabolism

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