Circadian rhythmicity in emerging mood disorders: state or trait marker?

A B Grierson; I B Hickie; S L Naismith; Daniel F Hermens; E M Scott; Jan Scott

doi:10.1186/s40345-015-0043-z

Back

Circadian rhythmicity in emerging mood disorders: state or trait marker?

Journal article

Open access

Peer reviewed

Circadian rhythmicity in emerging mood disorders: state or trait marker?

A B Grierson, I B Hickie, S L Naismith, Daniel F Hermens, E M Scott and Jan Scott

International Journal of Bipolar Disorders, Vol.4(3)

2016

DOI: https://doi.org/10.1186/s40345-015-0043-z

Files and links (2)

pdf

PDF - Published Version (Open Access)976.93 kBDownload View

Published VersionPDF - Published Version (Open Access)CC BY V4.0, Open Access

url

https://doi.org/10.1186/s40345-015-0043-zView

Published Version

Abstract

Clinical Sciences

circadian rhythm

bipolar

unipolar

adolescence

young adult

trait

Background: Circadian rhythm disturbances overlap with the symptoms of mood episodes and may trigger or prolong mood symptoms. There is limited research on the role of circadian disturbances in mood disorders in young people and/or first episode cases of unipolar and bipolar disorders. Methods: Actigraphy was undertaken for about 14 days in 63 post-pubertal individuals aged 13-25 years with a recent onset of a mood disorder meeting recognised diagnostic criteria. We examined associations between three easily interpretable markers of circadian rhythm activity (amplitude, acrophase and rhythmicity index) and demography and clinical characteristics. Then, circadian markers were compared between diagnostic groups, controlling for potential confounders. Results: Longer duration of illness was correlated with reduced circadian rhythmicity and lower levels of activity over 24 h. A delay in the timing of maximum activity was associated with the level of manic but not depressive symptoms. The circadian rhythmicity index differentiated unipolar from bipolar cases, and in bipolar but not unipolar disorder, the rhythmicity was less robust in those with more severe manic or depressive symptoms. Conclusions: Less robust circadian rhythmicity, especially associated with increasing symptom severity, may represent a more specific or a trait marker of young people with mood disorders who are at higher risk of a bipolar course of illness.

Details

Title: Circadian rhythmicity in emerging mood disorders: state or trait marker?
Authors: A B Grierson (Author) - University of Sydney
I B Hickie (Author) - University of Sydney
S L Naismith (Author) - University of Sydney
Daniel F Hermens (Author) - University of Sydney
E M Scott (Author) - University of Sydney
Jan Scott (Author) - Newcastle University, United Kingdom
Publication details: International Journal of Bipolar Disorders, Vol.4(3)
Publisher: SpringerOpen
Date published: 2016
DOI: 10.1186/s40345-015-0043-z
ISSN: 2194-7511
Copyright note: Copyright © 2016 Grierson et al. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
Organisation Unit: University of the Sunshine Coast, Queensland; Thompson Institute
Language: English
Record Identifier: 99450636802621
Output Type: Journal article

Metrics

9 File views/ downloads

293 Record Views

45 Times Cited - Web of Science

InCites Highlights

These are selected metrics from InCites Benchmarking & Analytics tool, related to this output

Collaboration types: Domestic collaboration; International collaboration
Web Of Science research areas: Psychiatry

UN Sustainable Development Goals (SDGs)

This output has contributed to the advancement of the following goals:

Source: InCites