Circadian profiles in young people during the early stages of affective disorder

S L Naismith; Daniel F Hermens; T K C Ip; S Bolitho; E Scott; N L Rogers; I B Hickie

doi:10.1038/tp.2012.47

Back

Circadian profiles in young people during the early stages of affective disorder

Journal article

Open access

Peer reviewed

Circadian profiles in young people during the early stages of affective disorder

S L Naismith, Daniel F Hermens, T K C Ip, S Bolitho, E Scott, N L Rogers and I B Hickie

Translational Psychiatry, Vol.2, e123

2012

DOI: https://doi.org/10.1038/tp.2012.47

Files and links (2)

pdf

PDF - Published Version (Open Access)295.50 kBDownload View

Published VersionPDF - Published Version (Open Access)CC BY-NC-ND V3.0, Open Access

url

https://doi.org/10.1038/tp.2012.47View

Published Version

Abstract

Although disturbances of the circadian system are strongly linked to affective disorders, no known studies have examined melatonin profiles in young people in early stages of illness. In this study, 44 patients with an affective disorder underwent clinical and neuropsychological assessments. They were then rated by a psychiatrist according to a clinical staging model and were categorized as having an 'attenuated syndrome' or an 'established disorder'. During the evening, salivary melatonin was sampled under dim light conditions over an 8-h interval and for each patient, the time of melatonin onset, total area under the curve and phase angle (difference between time of melatonin onset and time of habitual sleep onset) were computed. Results showed that there was no difference in the timing of melatonin onset across illness stages. However, area under the curve analyses showed that those patients with 'established disorders' had markedly reduced levels of melatonin secretion, and shorter phase angles, relative to those with 'attenuated syndromes'. These lower levels, in turn, were related to lower subjective sleepiness, and poorer performance on neuropsychological tests of verbal memory. Overall, these results suggest that for patients with established illness, dysfunction of the circadian system relates clearly to functional features and markers of underlying neurobiological change. Although the interpretation of these results would be greatly enhanced by control data, this work has important implications for the early delivery of chronobiological interventions in young people with affective disorders. © 2012 Macmillan Publishers Limited All rights reserved.

Details

Title: Circadian profiles in young people during the early stages of affective disorder
Authors: S L Naismith (Author) - University of Sydney
Daniel F Hermens (Author) - University of Sydney
T K C Ip (Author) - University of Sydney
S Bolitho (Author) - University of Sydney
E Scott (Author) - University of Sydney
N L Rogers (Author) - Central Queensland University
I B Hickie (Author) - University of Sydney
Publication details: Translational Psychiatry, Vol.2, e123; 6
Publisher: Nature Publishing Group
Date published: 2012
DOI: 10.1038/tp.2012.47
ISSN: 2158-3188
Copyright note: Copyright © 2012 Naismith et al. This work is licensed under the Creative Commons Attribution-NonCommercial-No Derivative Works 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/
Organisation Unit: University of the Sunshine Coast, Queensland; Thompson Institute
Language: English
Record Identifier: 99450538802621
Output Type: Journal article

Metrics

12 File views/ downloads

248 Record Views

55 Times Cited - Web of Science

InCites Highlights

These are selected metrics from InCites Benchmarking & Analytics tool, related to this output

Collaboration types: Domestic collaboration
Web Of Science research areas: Psychiatry

UN Sustainable Development Goals (SDGs)

This output has contributed to the advancement of the following goals:

Source: InCites