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Cigarette smoking in young adults - The influence of the HTR2A T102C polymorphism and punishment sensitivity179.78 kB
Accepted VersionCC BY-NC-ND V4.0, Open Access
Journal article
Cigarette smoking in young adults: The influence of the HTR2A T102C polymorphism and punishment sensitivity
Drug and Alcohol Dependence, Vol.114(2-3), pp.140-146
2011
PMID: 21035274
Abstract
Background:
The C allele of a common polymorphism of the serotonin 2A receptor (HTR2A) gene, T102C, results in reduced synthesis of 5-HT2A receptors and has been associated with current smoking status in adults. The -1438A/G polymorphism, located in the regulatory region of this gene, is in linkage disequilibrium with T102C, and the A allele is associated with increased promoter activity and with smoking in adult males. We investigated the contributions of the HTR2A gene, chronic psychological stress, and impulsivity to the prediction of cigarette smoking status and dependence in young adults.
Methods:
T102C and -1438A/G genotyping was conducted on 132 healthy Caucasian young adults (47 smokers) who completed self-report measures of chronic stress, depressive symptoms, impulsive personality and cigarette use.
Results:
A logistic regression analysis of current cigarette smoker user status, after adjusting for gender, depressive symptom severity and chronic stress, indicated that the T102C TT genotype relative to the CC genotype (OR = 7.53), and lower punishment sensitivity (OR = 0.91) were each significant predictive risk factors. However, for number of cigarettes smoked, only lower punishment sensitivity was a significant predictor (OR = 0.81).
Conclusions:
These data indicate the importance of the T102C polymorphism to tobacco use but not number of cigarettes smoked for Caucasian young adults. Future studies should examine whether this is explained by effects of nicotine on the serotonin system. Lower punishment sensitivity increased risk of both smoking and of greater consumption, perhaps via a reduced sensitivity to cigarette health warnings and negative physiological effects.
Details
- Title
- Cigarette smoking in young adults: The influence of the HTR2A T102C polymorphism and punishment sensitivity
- Authors
- Melanie White (Author) - Queensland University of TechnologyRoss Young (Author) - Queensland University of TechnologyC Phillip Morris (Author) - Queensland University of TechnologyBruce R Lawford (Author) - Queensland University of Technology
- Publication details
- Drug and Alcohol Dependence, Vol.114(2-3), pp.140-146
- Publisher
- Elsevier Ireland Ltd.
- Date published
- 2011
- DOI
- 10.1016/j.drugalcdep.2010.08.014
- ISSN
- 1879-0046; 0376-8716
- PMID
- 21035274
- Copyright note
- Copyright © 2011. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
- Organisation Unit
- University of the Sunshine Coast, Queensland; Office of the Deputy Vice-Chancellor (Research and Innovation)
- Language
- English
- Record Identifier
- 99551003602621
- Output Type
- Journal article
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- Psychiatry
- Substance Abuse
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