Chronic consumption of a high linoleic acid diet during pregnancy, lactation and post-weaning period increases depression-like behavior in male, but not female offspring

Suk-yu Yau; Yvette Siu Ling Yip; Douglas A. Formolo; Siyuen He; Thomas Ho Yin Lee; Chunyi Wen; Deanne H. Hryciw

doi:10.1016/j.bbr.2021.113538

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Chronic consumption of a high linoleic acid diet during pregnancy, lactation and post-weaning period increases depression-like behavior in male, but not female offspring

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Chronic consumption of a high linoleic acid diet during pregnancy, lactation and post-weaning period increases depression-like behavior in male, but not female offspring

Suk-yu Yau, Yvette Siu Ling Yip, Douglas A. Formolo, Siyuen He, Thomas Ho Yin Lee, Chunyi Wen and Deanne H. Hryciw

Behavioural Brain Research, Vol.416, pp.1-8

2022

DOI: https://doi.org/10.1016/j.bbr.2021.113538

PMID: 34418475

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Abstract

Autism spectrum disorder

Depression-like behavior

Linoleic acid

Maternal diet

Nutrition

Offspring

Polyunsaturated fatty acids (PUFAs) play an essential role in brain development. Emerging data have suggested a possible link between an imbalance in PUFAs and cognitive behavioral deficits in offspring. A diet rich in high linoleic acid (HLA), typically from preconception to lactation, leads to an increase in the ratio of omega-6 (n-6) to omega-3 (n-3) fatty acids in the fetus. Arising research has suggested that a deficiency in omega-3 fatty acids is a potential risk factor for inducing autism spectrum disorder (ASD)-like behavioral deficits. However, the impact of a high n- diet during preconception, pregnancy, lactation, and post-weaning on the brain development of adolescent offspring are yet to be determined. This study examined whether consumption of an HLA diet during pregnancy, lactation, and post-weaning induced social and cognitive impairments in female and male offspring rats that resemble autistic phenotypes in humans. Female Wistar Kyoto rats were fed with either HLA or low linoleic acid (LLA) control diet for 10 weeks before mating, then continued with the same diet throughout the pregnancy and lactation period. Female and male offspring at 5 weeks old were subjected to behavioral tests to assess social interaction behavior and depression-/anxiety-like behavior. Our result showed that chronic consumption of an HLA diet did not affect sociability and social recognition memory, but induced depression-like behavior in male but not in female offspring.

Details

Title: Chronic consumption of a high linoleic acid diet during pregnancy, lactation and post-weaning period increases depression-like behavior in male, but not female offspring
Authors: Suk-yu Yau (Corresponding Author) - Hong Kong Polytechnic University
Yvette Siu Ling Yip - Hong Kong Polytechnic University
Douglas A. Formolo - Hong Kong Polytechnic University
Siyuen He - Hong Kong Polytechnic University
Thomas Ho Yin Lee - Hong Kong Polytechnic University
Chunyi Wen - Hong Kong Polytechnic University
Deanne H. Hryciw - Griffith University
Publication details: Behavioural Brain Research, Vol.416, pp.1-8
Publisher: Elsevier BV
Date published: 2022
DOI: 10.1016/j.bbr.2021.113538
ISSN: 1872-7549; 0166-4328
PMID: 34418475
Grant note: This project was funded by the Collaborative Research Grant Scheme supported by the Faculty of Health and Social Sciences (Hong Kong Polytechnic University) and Griffith University, Brisbane, Australia, and the open research fund supported by State Key Laboratory of Brain and Cognitive Sciences at the University of Hong Kong.
Organisation Unit: School of Health - Biomedicine
Language: English
Record Identifier: 991186520102621
Output Type: Journal article

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