Choroidal Thickness in Indigenous Australian Children

Scott A Read; Rebecca A Cox; David Alonso-Caneiro; Shelley Hopkins; Joanne M Wood

doi:10.1167/tvst.9.12.28

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Choroidal Thickness in Indigenous Australian Children

Journal article

Open access

Peer reviewed

Choroidal Thickness in Indigenous Australian Children

Scott A Read, Rebecca A Cox, David Alonso-Caneiro, Shelley Hopkins and Joanne M Wood

Translational Vision Science & Technology, Vol.9(12), pp.1-10

2020

DOI: https://doi.org/10.1167/tvst.9.12.28

PMID: 33244448

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Abstract

choroid

childhood

Indigenous

refractive error

Purpose: This study aimed to examine the choroidal thickness profiles in visually normal Australian Indigenous children, given the important role of the choroid in refractive error and a range of ocular diseases. Methods: Choroidal thickness was assessed across the central 5 mm macular region using enhanced depth imaging spectral domain optical coherence tomography, in 250 children enrolled in an elementary school and a secondary school in rural Queensland, Australia. One hundred (40%) of these children identified as Indigenous Australians. Results: The subfoveal choroid was significantly thicker in Indigenous children (mean 369 ± 75 µm), compared to non-Indigenous children (355 ± 73 µm; P = 0.03). Subfoveal choroidal thickness was also significantly associated with age (β = +7.6, r2 = 0.105, P = 0.003), and axial length (β = −19.9, r2 = 0.030, P < 0.001). A significantly thicker choroid in Indigenous children was also found in analyses across the central 5 mm macular region (P = 0.008). A significant interaction between Indigenous status and meridian was observed (P = 0.007) with the largest differences between Indigenous and non-Indigenous children being in the nasal and inferonasal meridians. Conclusions: This study establishes the normative characteristics of macular choroidal thickness in Indigenous Australian children and demonstrates a significantly thicker choroid compared to non-Indigenous children from the same geographic region. These results may have implications for our understanding of factors predisposing or protecting Australian Indigenous people from a range of conditions associated with choroidal thickness. Translational Relevance: The significantly thicker choroid in Australian Indigenous children should be considered in clinical diagnoses and management of conditions associated with choroidal changes.

Details

Title: Choroidal Thickness in Indigenous Australian Children
Authors: Scott A Read (Corresponding Author) - Queensland University of Technology
Rebecca A Cox (Author) - Queensland University of Technology
David Alonso-Caneiro (Author) - Queensland University of Technology
Shelley Hopkins (Author) - Queensland University of Technology
Joanne M Wood (Author) - Queensland University of Technology
Publication details: Translational Vision Science & Technology, Vol.9(12), pp.1-10
Publisher: Association for Research in Vision and Ophthalmology
Date published: 2020
DOI: 10.1167/tvst.9.12.28
ISSN: 2164-2591
PMID: 33244448
Copyright note: This work is licensed under a Creative Commons Attribution 4.0 International License.
Organisation Unit: School of Science, Technology and Engineering
Language: English
Record Identifier: 99973593402621
Output Type: Journal article

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