Files and links (1)
Published VersionCC BY V4.0, Open Access
Journal article
Choroidal Thickening During Young Adulthood and Baseline Choroidal Thickness Predicts Refractive Error Change
Investigative Ophthalmology & Visual Science, Vol.63(5), pp.1-8
2022
PMID: 35616928
Abstract
PURPOSE. The purpose of this study was to explore the age-related change in choroidal thickness (ChT) and test the hypothesis that baseline ChT is predictive of refractive error change in healthy young adults.
METHODS. Participants underwent spectral-domain optical coherence tomography (SD-OCT) imaging and autorefraction at 20 (baseline) and 28 years old. The enhanced depth imaging mode on the SD-OCT was used to obtain images of the choroid. Scans were exported from the SD-OCT and analyzed with a custom software that automatically measures the central ChT. The longitudinal change in subfoveal ChT and association between baseline subfoveal ChT and 8-year change in refractive error (spherical equiva-lent) were determined using linear mixed models.
RESULTS. In total, 395 eyes of 198 participants (44% men; 18-22 years at baseline) were included. Over 8 years, mean spherical equivalent decreased by 0.25 diopters (D) and axial length increased by 0.09 mm. Subfoveal choroid thickened by 1.3 pm/year (95% confidence interval [CI] = 0.6-2.0), but this was reduced by 0.9 pm/year (95% CI = 1.6- 0.2) for every 1 mm increase in axial length. For every 10 pm increase in baseline ChT, average annual change in spherical equivalent and axial length reduced by 0.006 D/year and 0.003 mm/year, respectively.
CONCLUSIONS. In a community-based cohort of young adults, the choroid continued to change during early adulthood. Choroidal thickening was less in eyes that were longer at baseline, and the choroid thinned in eyes that showed myopia progression. The asso-ciation between baseline ChT and longitudinal changes in spherical equivalent and axial length supports the hypothesis that ChT may be predictive of refractive error develop-ment and/or myopia progression.
Details
- Title
- Choroidal Thickening During Young Adulthood and Baseline Choroidal Thickness Predicts Refractive Error Change
- Authors
- Samantha Sze-Yee Lee (Corresponding Author) - The University of Western AustraliaDavid Alonso-Caneiro (Author) - Queensland University of TechnologyGareth Lingham (Author) - The University of Western AustraliaFred K. Chen (Author) - The University of Western AustraliaPaul G. Sanfilippo (Author) - The University of MelbourneSeyhan Yazar (Author) - Garvan Institute of Medical ResearchDavid A. Mackey (Author) - The University of Western Australia
- Publication details
- Investigative Ophthalmology & Visual Science, Vol.63(5), pp.1-8
- Publisher
- Association for Research in Vision and Ophthalmology
- Date published
- 2022
- DOI
- 10.1167/iovs.63.5.34
- ISSN
- 1552-5783; 0146-0404
- PMID
- 35616928
- Copyright note
- This work is licensed under a Creative Commons Attribution 4.0 International License.
- Organisation Unit
- School of Science, Technology and Engineering
- Language
- English
- Record Identifier
- 99973594902621
- Output Type
- Journal article
Metrics
8 Record Views
InCites Highlights
These are selected metrics from InCites Benchmarking & Analytics tool, related to this output
- Collaboration types
- Domestic collaboration
- International collaboration
- Web Of Science research areas
- Ophthalmology
UN Sustainable Development Goals (SDGs)
This output has contributed to the advancement of the following goals:
Source: InCites