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Journal article
Choroidal Changes During and After Discontinuing Long-Term 0.01% Atropine Treatment for Myopia Control
Investigative Ophthalmology & Visual Science, Vol.65(10), pp.1-13
2024
PMID: 39136629
Abstract
Purpose: Few studies have explored choroidal changes after cessation of myopia control. This study evaluated the choroidal thickness (ChT) and choroidal vascularity index (CVI) during and after discontinuing long-term low-concentration atropine eye drops use for myopia control.
Methods: Children with progressive myopia (6–16 years; n = 153) were randomized to receive 0.01% atropine eye drops or a placebo (2:1 ratio) instilled daily over 2 years, followed by a 1-year washout (no eye drop use). Optical coherence tomography imaging of the choroid was conducted at the baseline, 2-year (end of treatment phase), and 3-year (end of washout phase) visits. The main outcome measure was the subfoveal ChT. Secondary measures include the CVI.
Results: During the treatment phase, the subfoveal choroids in both treatment and control groups thickened by 12–14 µm (group difference P = 0.56). During the washout phase, the subfoveal choroids in the placebo group continued to thicken by 6.6 µm (95% confidence interval [CI] = 1.7 to 11.6), but those in the atropine group did not change (estimate = -0.04 µm; 95% CI = –3.2 to 3.1). Participants with good axial eye growth control had greater choroidal thickening than the fast-progressors during the treatment phase regardless of the treatment group (P < 0.001), but choroidal thickening in the atropine group's fast-progressors was not sustained after stopping eye drops. CVI decreased in both groups during the treatment phase, but increased in the placebo group after treatment cessation.
Conclusions: On average, compared to placebo, 0.01% atropine eye drop treatment did not cause a differential rate of change in ChT during treatment, but abrupt cessation of long-term 0.01% atropine eye drops may disrupt normal choroidal thickening in children.
Details
- Title
- Choroidal Changes During and After Discontinuing Long-Term 0.01% Atropine Treatment for Myopia Control
- Authors
- Samantha Sze-Yee Lee (Corresponding Author) - The University of Western AustraliaGareth Lingham (Author) - The University of Western AustraliaAntony Clark (Author) - The University of Western AustraliaScott A. Read (Author) - Queensland University of TechnologyDavid Alonso-Caneiro (Author) - University of the Sunshine Coast, Queensland, School of Science, Technology and EngineeringDavid A. Mackey (Author) - The University of Western Australia
- Publication details
- Investigative Ophthalmology & Visual Science, Vol.65(10), pp.1-13
- Publisher
- Association for Research in Vision and Ophthalmology
- Date published
- 2024
- DOI
- 10.1167/iovs.65.10.21
- ISSN
- 1552-5783; 0146-0404
- PMID
- 39136629
- Copyright note
- This work is licensed under a Creative Commons Attribution 4.0 International License
- Grant note
- Supported by the Telethon-Perth Children’s Hospital Research Fund; University of Western Australia Research Collaboration Award; University of Western Australia Faculty of Health and Medical Sciences Early Career Researcher Small Grant Award; Australian Vision Research (the Ophthalmic Research Institute of Australia); Healy Medical Research Foundation Research Collaboration Award. Mackey is funded by a National Health and National Research Council (NHMRC) Practitioner Fellowship. Lee is funded by a Western Australia Future Health and Research Innovation Emerging Leaders Fellowship.
- Organisation Unit
- School of Science, Technology and Engineering
- Language
- English
- Record Identifier
- 991057798202621
- Output Type
- Journal article
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