Chlamydia trachomatis from Australian Aboriginal people with trachoma are polyphyletic composed of multiple distinctive lineages

P Andersson; Simon R Harris; H M B S Smith; James Hadfield; C O'Neill; L T Cutcliffe; F P Douglas; L V Asche; J D Mathews; S I Hutton; Derek S Sarovich; S Y C Tong; I N Clarke; N R Thomson; P M Giffard

doi:10.1038/ncomms10688

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Chlamydia trachomatis from Australian Aboriginal people with trachoma are polyphyletic composed of multiple distinctive lineages

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Chlamydia trachomatis from Australian Aboriginal people with trachoma are polyphyletic composed of multiple distinctive lineages

P Andersson, Simon R Harris, H M B S Smith, James Hadfield, C O'Neill, L T Cutcliffe, F P Douglas, L V Asche, J D Mathews, S I Hutton, …

Nature Communications, Vol.7(10688)

2016

DOI: https://doi.org/10.1038/ncomms10688

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Abstract

chlamydia trachomatis

OMPA outer membrane proteins

outer membrane protein

PmpG protein

PmpH protein

adult

Australia

bacterial genome

child

DNA barcoding

endemic disease

epidemiology

ethnology

gene

Chlamydia trachomatis causes sexually transmitted infections and the blinding disease trachoma. Current data on C. trachomatis phylogeny show that there is only a single trachoma-causing clade, which is distinct from the lineages causing urogenital tract (UGT) and lymphogranuloma venerum diseases. Here we report the whole-genome sequences of ocular C. trachomatis isolates obtained from young children with clinical signs of trachoma in a trachoma endemic region of northern Australia. The isolates form two lineages that fall outside the classical trachoma lineage, instead being placed within UGT clades of the C. trachomatis phylogenetic tree. The Australian trachoma isolates appear to be recombinants with UGT C. trachomatis genome backbones, in which loci that encode immunodominant surface proteins (ompA and pmpEFGH) have been replaced by those characteristic of classical ocular isolates. This suggests that ocular tropism and association with trachoma are functionally associated with some sequence variants of ompA and pmpEFGH.

Details

Title: Chlamydia trachomatis from Australian Aboriginal people with trachoma are polyphyletic composed of multiple distinctive lineages
Authors: P Andersson (Author) - Charles Darwin University
Simon R Harris (Author) - Wellcome Trust Sanger Institute, United Kingdom
H M B S Smith (Author) - Wellcome Trust Sanger Institute, United Kingdom
James Hadfield (Author) - Wellcome Trust Sanger Institute, United Kingdom
C O'Neill (Author) - Southampton General Hospital, United Kingdom
L T Cutcliffe (Author) - Southampton General Hospital, United Kingdom
F P Douglas (Author) - Menzies School of Health Research
L V Asche (Author) - Menzies School of Health Research
J D Mathews (Author) - Menzies School of Health Research
S I Hutton (Author) - Charles Darwin University
Derek S Sarovich (Author) - Charles Darwin University
S Y C Tong (Author) - Charles Darwin University
I N Clarke (Author) - Southampton General Hospital, United Kingdom
N R Thomson (Author) - Wellcome Trust Sanger Institute, United Kingdom
P M Giffard (Author) - Charles Darwin University
Publication details: Nature Communications, Vol.7(10688); 11
Publisher: Nature Publishing Group
Date published: 2016
DOI: 10.1038/ncomms10688
ISSN: 2041-1723
Copyright note: Copyright © 2016 The Author. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
Organisation Unit: University of the Sunshine Coast, Queensland; Centre for Bioinnovation
Language: English
Record Identifier: 99450597302621
Output Type: Journal article

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Web Of Science research areas: Microbiology

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