Chlamydia trachomatis Genital Tract Infections: When Host Immune Response and the Microbiome Collide

Noa Ziklo; Wilhelmina M Huston; Jane S Hocking; Peter Timms

doi:10.1016/j.tim.2016.05.007

Back

Chlamydia trachomatis Genital Tract Infections: When Host Immune Response and the Microbiome Collide

Journal article

Open access

Peer reviewed

Chlamydia trachomatis Genital Tract Infections: When Host Immune Response and the Microbiome Collide

Noa Ziklo, Wilhelmina M Huston, Jane S Hocking and Peter Timms

Trends in Microbiology, Vol.24(9), pp.750-765

2016

DOI: https://doi.org/10.1016/j.tim.2016.05.007

Files and links (2)

pdf

PDF - Author's Accepted Version (Open Access)819.56 kBDownload View

Accepted VersionPDF - Author Accepted Version (Open Access)CC BY-NC-ND V4.0, Open Access

url

https://doi.org/10.1016/j.tim.2016.05.007View

Published Version

Abstract

Genital infections with Chlamydia trachomatis continue to be a major health problem worldwide. While some individuals clear their infection (presumed to be the result of an effective Th1/interferon-γ response), others develop chronic infections and some are prone to repeat infections. In females in particular, chronic asymptomatic infections are common and can lead to pelvic inflammatory disease and infertility. Recent studies suggest that the genital tract microbiota could be a significant factor and explain person-to-person variation in C. trachomatis infections. One hypothesis suggests that C. trachomatis can use its trpBA genes to rescue tryptophan from indole, which is a product of anaerobic members of the genital tract microbiota. Women with particular microbiota types, such as seen in bacterial vaginosis, have increased numbers of anaerobes, and this would enable the chlamydia in these individuals to overcome the host's interferon-γ attempts to eliminate it, resulting in more repeat and/or chronic infections.

Details

Title: Chlamydia trachomatis Genital Tract Infections: When Host Immune Response and the Microbiome Collide
Authors: Noa Ziklo (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and Engineering
Wilhelmina M Huston (Author) - University of Technology, Sydney
Jane S Hocking (Author) - University of Melbourne
Peter Timms (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and Engineering
Publication details: Trends in Microbiology, Vol.24(9), pp.750-765
Publisher: Elsevier Ltd.
Date published: 2016
DOI: 10.1016/j.tim.2016.05.007
ISSN: 0966-842X
Organisation Unit: School of Science and Engineering - Legacy; University of the Sunshine Coast, Queensland; Centre for Bioinnovation
Language: English
Record Identifier: 99449770202621
Output Type: Journal article

Metrics

149 File views/ downloads

774 Record Views

68 Times Cited - Web of Science

InCites Highlights

These are selected metrics from InCites Benchmarking & Analytics tool, related to this output

Collaboration types: Domestic collaboration
Web Of Science research areas: Biochemistry & Molecular Biology; Microbiology

UN Sustainable Development Goals (SDGs)

This output has contributed to the advancement of the following goals:

Source: InCites