Journal article
Chlamydia pneumoniae DNA is not detectable within sarcoidosis tissue
Pathology, Vol.30(3), pp.293-296
1998
Abstract
Sarcoidosis is a granulomatous disease of unknown etiology. Recent studies have suggested the possibility of a bacterial origin with Chlamydia pneumoniae being one of the many bacteria considered. The aim of this study was to use the polymerase chain reaction (PCR) in an attempt to identify C. pneumoniae within fresh/frozen sarcoidosis tissue. Tissue from 20 sarcoidosis patients and 17 controls was evaluated, DNA was extracted from all tissue specimens and PCR amplified with primers specific for C. pneumoniae. All study tissues were negative for the presence of DNA sequences from C. pneumoniae. These findings could not be attributed to PCR inhibition or to lack of sensitivity of the PCR assay. The negative finding suggests either that there is no involvement between C. pneumoniae and sarcoidosis or that, having incited granulomata formation, it is no longer present in detectable amounts.
Details
- Title
- Chlamydia pneumoniae DNA is not detectable within sarcoidosis tissue
- Authors
- G D Mills (Author) - Queensland University of TechnologyR K A Allen (Author) - Prince Charles HospitalPeter Timms (Author) - Queensland University of Technology
- Publication details
- Pathology, Vol.30(3), pp.293-296
- Publisher
- Lippincott Williams & Wilkins Ltd.
- Date published
- 1998
- DOI
- 10.1080/00313029800169476
- ISSN
- 0031-3025
- Organisation Unit
- University of the Sunshine Coast, Queensland; Centre for Bioinnovation
- Language
- English
- Record Identifier
- 99449797002621
- Output Type
- Journal article
Metrics
514 Record Views
InCites Highlights
These are selected metrics from InCites Benchmarking & Analytics tool, related to this output
- Collaboration types
- Domestic collaboration
- International collaboration
- Web Of Science research areas
- Pathology
UN Sustainable Development Goals (SDGs)
This output has contributed to the advancement of the following goals:
Source: InCites