Chlamydia muridarum Major Outer Membrane Protein-Specific Antibodies Inhibit In Vitro Infection but Enhance Pathology In Vivo

K A Cunningham; A J Carey; L M Hafner; Peter Timms; K W Beagley

doi:10.1111/j.1600-0897.2010.00894.x

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Chlamydia muridarum Major Outer Membrane Protein-Specific Antibodies Inhibit In Vitro Infection but Enhance Pathology In Vivo

Journal article

Open access

Peer reviewed

Chlamydia muridarum Major Outer Membrane Protein-Specific Antibodies Inhibit In Vitro Infection but Enhance Pathology In Vivo

K A Cunningham, A J Carey, L M Hafner, Peter Timms and K W Beagley

American Journal of Reproductive Immunology, Vol.65(2), pp.118-126

2011

DOI: https://doi.org/10.1111/j.1600-0897.2010.00894.x

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Abstract

hydrosalpinx

immunopathology

oviduct

Problem: Chlamydia trachomatis is a significant worldwide health problem, and the often-asymptomatic disease can result in infertility. To develop a successful vaccine, a complete understanding of the immune response to chlamydial infection and development of genital tract pathology is required. Method of Study We utilized the murine genital model of chlamydial infection. Mice were immunized with chlamydial major outer membrane protein, and vaginal lavage was assessed for the presence of neutralizing antibodies. These samples were then pre-incubated with Chlamydia muridarum and administered to the vaginal vaults of immune-competent female BALBâ„ c mice to determine the effect on infection. Results The administration of C. muridarum in conjunction with neutralizing antibodies reduced the numbers of mice infected, but a surprising finding was that this accelerated the development of severe oviduct pathology. Conclusion Antibodies play an under-recognized role in chlamydial infection and pathology development, which possibly involves interaction with Th1 immunity.

Details

Title: Chlamydia muridarum Major Outer Membrane Protein-Specific Antibodies Inhibit In Vitro Infection but Enhance Pathology In Vivo
Authors: K A Cunningham (Author) - Queensland University of Technology
A J Carey (Author) - Queensland University of Technology
L M Hafner (Author) - Queensland University of Technology
Peter Timms (Author) - Queensland University of Technology
K W Beagley (Author) - Queensland University of Technology
Publication details: American Journal of Reproductive Immunology, Vol.65(2), pp.118-126
Publisher: Wiley-Blackwell Publishing Inc.
Date published: 2011
DOI: 10.1111/j.1600-0897.2010.00894.x
ISSN: 1046-7408
Copyright note: Copyright © 2011 Wiley-Blackwell Publishing Inc. This is the accepted version of the following article: Cunningham, K. A., Carey, A. J., Hafner, L., Timms, P. and Beagley, K. W. (2011), Chlamydia muridarum Major Outer Membrane Protein-Specific Antibodies Inhibit In Vitro Infection but Enhance Pathology In Vivo. American Journal of Reproductive Immunology, 65: 118-126. doi: 10.1111/j.1600-0897.2010.00894.x, which has been published in final form at http://dx.doi.org/10.1111/j.1600-0897.2010.00894.x
Organisation Unit: University of the Sunshine Coast, Queensland; Centre for Bioinnovation
Language: English
Record Identifier: 99448966602621
Output Type: Journal article

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