Journal article
Childhood adversity impacts on brain subcortical structures relevant to depression
Journal of Psychiatric Research, Vol.86, pp.58-65
2017
Abstract
Childhood adversity plays an important role for development of major depressive disorder (MDD). There are differences in subcortical brain structures between patients with MDD and healthy controls, but the specific impact of childhood adversity on such structures in MDD remains unclear. Thus, aim of the present study was to investigate whether childhood adversity is associated with subcortical volumes and how it interacts with a diagnosis of MDD and sex. Within the ENIGMA-MDD network, nine university partner sites, which assessed childhood adversity and magnetic resonance imaging in patients with MDD and controls, took part in the current joint mega-analysis. In this largest effort world-wide to identify subcortical brain structure differences related to childhood adversity, 3036 participants were analyzed for subcortical brain volumes using FreeSurfer. A significant interaction was evident between childhood adversity, MDD diagnosis, sex, and region. Increased exposure to childhood adversity was associated with smaller caudate volumes in females independent of MDD. All subcategories of childhood adversity were negatively associated with caudate volumes in females - in particular emotional neglect and physical neglect (independently from age, ICV, imaging site and MDD diagnosis). There was no interaction effect between childhood adversity and MDD diagnosis on subcortical brain volumes. Childhood adversity is one of the contributors to brain structural abnormalities. It is associated with subcortical brain abnormalities that are relevant to psychiatric disorders such as depression.
Details
- Title
- Childhood adversity impacts on brain subcortical structures relevant to depression
- Authors
- Thomas Frodl (Author) - Otto von Guericke University of Magdeburg, GermanyDeborah Janowitz (Author) - University Medicine Greifswald, GermanyLianne Schmaal (Author) - VU University Medical Centre, NetherlandsLeonard Tozzi (Author) - Otto von Guericke University of Magdeburg, GermanyHenrik Dobrowolny (Author) - Otto von Guericke University of Magdeburg, GermanyDan J Stein (Author) - University of Cape Town, South AfricaDick J Veltman (Author) - VU University Medical Centre, NetherlandsKatharina Wittfeld (Author) - German Centre for Neurodegenerative Diseases (DZNE), GermanyTheo G M van Erp (Author) - University of California, United StatesNeda Jahanshad (Author) - University of Southern California, United StatesAndrea Block (Author) - University Medicine Greifswald, GermanyKatrin Hegenscheid (Author) - University Medicine Greifswald, GermanyHenry Volzke (Author) - University Medicine Greifswald, GermanyJim Lagopoulos (Author) - University of the Sunshine CoastSean N Hatton (Author) - University of SydneyIan B Hickie (Author) - University of SydneyEva Maria Frey (Author) - University of Regensburg, GermanyAngela Carballedo (Author) - Otto von Guericke University of Magdeburg, GermanySamantha J Brooks (Author) - University of Cape Town, South AfricaDaniella Vuletic (Author) - University of Cape Town, South AfricaAnne Uhlmann (Author) - University of Cape Town, South AfricaIlya M Veer (Author) - Charite Universitatsmedizin Berlin, GermanyHenrik Walter (Author) - Charite Universitatsmedizin Berlin, GermanyKnut Schnell (Author) - University Hospital Heidelberg, GermanyDominik Grotegerd (Author) - University of Münster, GermanyVolker Arolt (Author) - University of Münster, GermanyHarald Kugel (Author) - University of Münster, GermanyElisabeth Schramm (Author) - University Medical Centre Freiburg, GermanyCarsten Konrad (Author) - Agaplesion Diakoniklinikum, GermanyBartosz Zurowski (Author) - University of Lubeck, GermanyBernhard T Baune (Author) - University of AdelaideNic J A van der Wee (Author) - Leiden Institute for Brain and Cognition and Leiden Center for Translational Neuroscience, NetherlandsMarie-Jose van Tol (Author) - University of Groningen, NetherlandsBrenda W J H Penninx (Author) - VU University Medical Center, NetherlandsPaul M Thompson (Author) - University of Southern California, United StatesDerrek P Hibar (Author) - University of Southern California, United StatesUdo Dannlowski (Author) - University of Münster, GermanyHans J Grabe (Author) - University Medicine Greifswald, Germany
- Publication details
- Journal of Psychiatric Research, Vol.86, pp.58-65
- Publisher
- Pergamon
- Date published
- 2017
- DOI
- 10.1016/j.jpsychires.2016.11.010
- ISSN
- 0022-3956
- Copyright note
- Copyright © 2017. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
- Organisation Unit
- University of the Sunshine Coast, Queensland; Thompson Institute
- Language
- English
- Record Identifier
- 99450922502621
- Output Type
- Journal article
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- Domestic collaboration
- International collaboration
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- Psychiatry
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Source: InCites