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Published VersionCC BY V4.0, Open Access
Journal article
Chikungunya virus in Asia–Pacific: a systematic review
Emerging Microbes and Infections, Vol.8(1), pp.70-79
2019
Abstract
Chikungunya virus (CHIKV) is a mosquito-borne pathogen that causes an acute febrile syndrome and severe, debilitating rheumatic disorders in humans that may persist for months. CHIKV's presence in Asia dates from at least 1954, but its epidemiological profile in the region remains poorly understood. We systematically reviewed CHIKV emergence, epidemiology, clinical features, atypical manifestations and distribution of virus genotypes, in 47 countries from South East Asia (SEA) and the Western Pacific Region (WPR) during the period 1954-2017. Following the Cochrane Collaboration guidelines, Pubmed and Scopus databases, surveillance reports available in the World Health Organisation (WHO) and government websites were systematically reviewed. Of the 3504 records identified, 461 were retained for data extraction. Although CHIKV has been circulating in Asia almost continuously since the 1950s, it has significantly expanded its geographic reach in the region from 2005 onwards. Most reports identified in the review originated from India. Although all ages and both sexes can be affected, younger children and the elderly are more prone to severe and occasionally fatal forms of the disease, with child fatalities recorded since 1963 from India. The most frequent clinical features identified were arthralgia, rash, fever and headache. Both the Asian and East-Central-South African (ECSA) genotypes circulate in SEA and WPR, with ECSA genotype now predominant. Our findings indicate a substantial but poorly documented burden of CHIKV infection in the Asia-Pacific region. An evidence-based consensus on typical clinical features of chikungunya could aid in enhanced diagnosis and improved surveillance of the disease.
Details
- Title
- Chikungunya virus in Asia–Pacific: a systematic review
- Authors
- B M C R Wimalasiri-Yapa (Author) - Queensland University of TechnologyL Stassen (Author) - Queensland University of TechnologyX Huang (Author) - Queensland University of TechnologyL M Hafner (Author) - Queensland University of TechnologyW Hu (Author) - Queensland University of TechnologyG J Devine (Author)L Yakob (Author)C C Jansen (Author) - Queensland GovernmentHelen M Faddy (Author) - Australian Red Cross Blood ServiceE Viennet (Author) - Australian Red Cross Blood ServiceF D Frentiu (Author) - Queensland University of Technology
- Publication details
- Emerging Microbes and Infections, Vol.8(1), pp.70-79
- Publisher
- Nature Publishing Group
- Date published
- 2019
- DOI
- 10.1080/22221751.2018.1559708
- ISSN
- 2222-1751
- Copyright note
- © 2019 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group, on behalf of Shanghai Shangyixun Cultural Communication Co., Ltd This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- Organisation Unit
- School of Health - Biomedicine; School of Health; School of Health and Sport Sciences - Legacy; School of Health and Behavioural Sciences - Legacy
- Language
- English
- Record Identifier
- 99451106502621
- Output Type
- Journal article
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- Immunology
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