Chemical Characterization, α-Glucosidase, α-Amylase and Lipase Inhibitory Properties of the Australian Honey Bee Propolis

Sabah Uddin; Peter R. Brooks; Trong D. Tran

doi:10.3390/foods11131964

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Chemical Characterization, α-Glucosidase, α-Amylase and Lipase Inhibitory Properties of the Australian Honey Bee Propolis

Journal article

Open access

Peer reviewed

Chemical Characterization, α-Glucosidase, α-Amylase and Lipase Inhibitory Properties of the Australian Honey Bee Propolis

Sabah Uddin, Peter R. Brooks and Trong D. Tran

Foods, Vol.11(13), pp.1-18

2022

DOI: https://doi.org/10.3390/foods11131964

PMCID: PMC9266216

PMID: 35804780

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Abstract

anti-obesity

antidiabetics

Australian honey bee propolis

propolins

α-amylase

α-glucosidase

The use of functional foods and nutraceuticals as a complementary therapy for the prevention and management of type 2 diabetes and obesity has steadily increased over the past few decades. With the aim of exploring the therapeutic potentials of Australian propolis, this study reports the chemical and biological investigation of a propolis sample collected in the Queensland state of Australia which exhibited a potent activity in an in vitro α-glucosidase inhibitory screening. The chemical investigation of the propolis resulted in the identification of six known prenylated flavonoids including propolins C, D, F, G, H, and solophenol D. These compounds potently inhibited the α-glucosidase and two other enzymes associated with diabetes and obesity, α-amylase, and lipase on in vitro and in silico assays. These findings suggest that this propolis is a potential source for the development of a functional food to prevent type 2 diabetes and obesity. The chemical analysis revealed that this propolis possessed a chemical fingerprint relatively similar to the Pacific propolis found in Okinawa (South of Japan), Taiwan, and the Solomon Islands. This is the first time the Pacific propolis has been identified in Australia.

Details

Title: Chemical Characterization, α-Glucosidase, α-Amylase and Lipase Inhibitory Properties of the Australian Honey Bee Propolis
Authors: Sabah Uddin (Author) - University of the Sunshine Coast, Queensland, School of Science, Technology and Engineering
Peter R. Brooks (Author) - University of the Sunshine Coast, Queensland, School of Science, Technology and Engineering
Trong D. Tran (Author) - University of the Sunshine Coast, Queensland, School of Science, Technology and Engineering
Publication details: Foods, Vol.11(13), pp.1-18
Publisher: MDPI AG
Date published: 2022
DOI: 10.3390/foods11131964
ISSN: 2304-8158
PMID: 35804780; PMC9266216
Organisation Unit: University of the Sunshine Coast, Queensland; School of Science, Technology and Engineering; Centre for Bioinnovation
Language: English
Record Identifier: 99656594402621
Output Type: Journal article

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