Charged Solvatochromic Dyes as Signal Transducers in pH Independent Fluorescent and Colorimetric Ion Selective Nanosensors

Xiaojiang Xie; Agustin Gutierrez; Valentin Trofimov; Istvan Szcilagyi; Thierry Soldati; Eric Bakker

doi:10.1021/acs.analchem.5b02566

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Charged Solvatochromic Dyes as Signal Transducers in pH Independent Fluorescent and Colorimetric Ion Selective Nanosensors

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Charged Solvatochromic Dyes as Signal Transducers in pH Independent Fluorescent and Colorimetric Ion Selective Nanosensors

Xiaojiang Xie, Agustin Gutierrez, Valentin Trofimov, Istvan Szcilagyi, Thierry Soldati and Eric Bakker

Analytical Chemistry, Vol.87(19), pp.9954-9959

2015

DOI: https://doi.org/10.1021/acs.analchem.5b02566

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Abstract

Analytical Chemistry

Chemical Engineering

Other Chemical Sciences

Ionophore-based ion selective optical nanosensors that operate independently of the sample pH are developed here by the use of electrically charged solvatochromic dyes as signal transducers. A series of dye molecules with a D-π-A structure was synthesized and characterized in various solvents and incorporated into ion selective nanospheres for K+, Na+, and H+. Since dye leakage was greatly suppressed when the solvatochromic dyes were encapsulated in the nanosphere core, ion sensing nanospheres were explored for cellular ion imaging in Dictyostelium discoideum live cells but spontaneous dye loss resulted in undesired staining of cells. The in vitro analysis of potassium in human plasma was successfully demonstrated with this approach. A theoretical model was developed for the response of the ion selective nanosensors containing charged solvatochromic dyes. The nanosensors exhibited a tunable response range, high sensitivity, and good stability.

Details

Title: Charged Solvatochromic Dyes as Signal Transducers in pH Independent Fluorescent and Colorimetric Ion Selective Nanosensors
Authors: Xiaojiang Xie (Author) - University of Geneva, Switzerland
Agustin Gutierrez (Author) - University of Geneva, Switzerland
Valentin Trofimov (Author) - University of Geneva, Switzerland
Istvan Szcilagyi (Author) - University of Geneva, Switzerland
Thierry Soldati (Author) - University of Geneva, Switzerland
Eric Bakker (Author) - University of Geneva, Switzerland
Publication details: Analytical Chemistry, Vol.87(19), pp.9954-9959
Publisher: American Chemical Society
Date published: 2015
DOI: 10.1021/acs.analchem.5b02566
ISSN: 0003-2700
Organisation Unit: University of the Sunshine Coast, Queensland
Language: English
Record Identifier: 99450204602621
Output Type: Journal article

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