Characterization of three venom peptides from the spitting spider Scytodes thoracica

N K Ariki; L E Muñoz; E L Armitage; F R Goodstein; K G George; V L Smith; I Vetter; Volker Herzig; G F King; N M Loening

doi:10.1371/journal.pone.0156291

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Characterization of three venom peptides from the spitting spider Scytodes thoracica

Journal article

Open access

Peer reviewed

Characterization of three venom peptides from the spitting spider Scytodes thoracica

N K Ariki, L E Muñoz, E L Armitage, F R Goodstein, K G George, V L Smith, I Vetter, Volker Herzig, G F King and N M Loening

PLoS One, Vol.11(5), e0156291

2016

DOI: https://doi.org/10.1371/journal.pone.0156291

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Abstract

We present the solution-state NMR structures and preliminary functional characterizations of three venom peptides identified from the spitting spider Scytodes thoracica. Despite little sequence identity to other venom peptides, structural characterization reveals that these peptides contain an inhibitor cystine knot motif common to many venom peptides. These are the first structures for any peptide or protein from spiders of the Scytodidae family. Many venom peptides target neuronal ion channels or receptors. However, we have not been able to determine the target of these Scytodes peptides so we can only state with certainty the channels and receptors that they do not target.

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Title: Characterization of three venom peptides from the spitting spider Scytodes thoracica
Authors: N K Ariki (Author)
L E Muñoz (Author)
E L Armitage (Author)
F R Goodstein (Author)
K G George (Author)
V L Smith (Author)
I Vetter (Author)
Volker Herzig (Author) - University of Queensland
G F King (Author)
N M Loening (Author)
Publication details: PLoS One, Vol.11(5), e0156291
Publisher: Public Library of Science
Date published: 2016
DOI: 10.1371/journal.pone.0156291
ISSN: 1932-6203
Copyright note: Copyright © 2016 Ariki et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Organisation Unit: School of Science and Engineering - Legacy; University of the Sunshine Coast, Queensland; School of Science, Technology and Engineering; Centre for Bioinnovation
Language: English
Record Identifier: 99451324502621
Output Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Web Of Science research areas: Biochemistry & Molecular Biology

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