Characterization of schizophrenia adverse drug interactions through a network approach and drug classification

J Sun; Min Zhao; A H Fanous; Z Zhao

doi:10.1155/2013/458989

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Characterization of schizophrenia adverse drug interactions through a network approach and drug classification

Journal article

Open access

Peer reviewed

Characterization of schizophrenia adverse drug interactions through a network approach and drug classification

J Sun, Min Zhao, A H Fanous and Z Zhao

BioMed Research International, Vol.2013, pp.1-10

2013

DOI: https://doi.org/10.1155/2013/458989

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Abstract

acetophenazine

amisulpride

aripiprazole

atypical antipsychotic agent

chlorpromazine

chlorprothixene

clozapine

desvenlafaxine

flupentixol

fluphenazine

haloperidol

levomepromazine

loxapine

mesoridazine

molindone

neuroleptic agent

olanzapine

Antipsychotic drugs are medications commonly for schizophrenia (SCZ) treatment, which include two groups: typical and atypical. SCZ patients have multiple comorbidities, and the coadministration of drugs is quite common. This may result in adverse drug-drug interactions, which are events that occur when the effect of a drug is altered by the coadministration of another drug. Therefore, it is important to provide a comprehensive view of these interactions for further coadministration improvement. Here, we extracted SCZ drugs and their adverse drug interactions from the DrugBank and compiled a SCZ-specific adverse drug interaction network. This network included 28 SCZ drugs, 241 non-SCZs, and 991 interactions. By integrating the Anatomical Therapeutic Chemical (ATC) classification with the network analysis, we characterized those interactions. Our results indicated that SCZ drugs tended to have more adverse drug interactions than other drugs. Furthermore, SCZ typical drugs had significant interactions with drugs of the "alimentary tract and metabolism" category while SCZ atypical drugs had significant interactions with drugs of the categories "nervous system" and "antiinfectives for systemic uses." This study is the first to characterize the adverse drug interactions in the course of SCZ treatment and might provide useful information for the future SCZ treatment. © 2013 Jingchun Sun et al.

Details

Title: Characterization of schizophrenia adverse drug interactions through a network approach and drug classification
Authors: J Sun (Author) - Vanderbilt University School of Medicine, United States
Min Zhao (Author) - Vanderbilt University School of Medicine, United States
A H Fanous (Author) - Virginia Commonwealth University, United States
Z Zhao (Author) - Vanderbilt University School of Medicine, United States
Publication details: BioMed Research International, Vol.2013, pp.1-10
Publisher: Hindawi Publishing Corporation
Date published: 2013
DOI: 10.1155/2013/458989
ISSN: 2314-6133
Copyright note: Copyright © 2013 Jingchun Sun et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Organisation Unit: School of Science and Engineering - Legacy; University of the Sunshine Coast, Queensland; School of Science, Technology and Engineering; Centre for Bioinnovation
Language: English
Record Identifier: 99448795502621
Output Type: Journal article

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