Characteristics of hospital and community-acquired methicillin resistant Staphylococcus aureus in Tehran, Iran

Fateh Rahimi; Mohammad Katouli; Mohammad Reza Pourshafie

doi:10.1099/jmm.0.070722-0

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Characteristics of hospital and community-acquired methicillin resistant Staphylococcus aureus in Tehran, Iran

Journal article

Open access

Peer reviewed

Characteristics of hospital and community-acquired methicillin resistant Staphylococcus aureus in Tehran, Iran

Fateh Rahimi, Mohammad Katouli and Mohammad Reza Pourshafie

Journal of Medical Microbiology, Vol.63(6), pp.796-804

2014

DOI: https://doi.org/10.1099/jmm.0.070722-0

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Abstract

antimicrobial resistance

epidemiological typing

meticillin resistance

nosocomial infections

staphylococcus aureus

Staphylococcus aureus is a leading cause of hospital-(HA) and the community-acquired (CA) infections worldwide. Recently, S. aureus strains resistant to methicillin (MRSA) have become established within both communities. We isolated 314 isolates of MRSA from hospitalized patients in a referral hospital (HA isolates) and its outpatient clinic (n=268) (CA-isolates) in Tehran, Iran between February 2008 and December 2010. These isolates were tested for their susceptibility to 17 antibiotics and typed using the PhPlate system. The diversity in the structure of SCCmec elements and ccr types were also detected using a multiplex-PCR assay and isolates were examined for the presence of different classes of prophages. Whilst all isolates were resistant to penicillin, the HA-isolates were significantly more resistant to all other antibiotics tested than the CA-isolates. Isolates carrying only SCCmec type III and ccr type 3 were dominant (91%), but 20% of the CA-isolates belonging to less prevalent types, carried only SCCmec types IVa, c and ccr type 2. These isolates also carried pvl gene and contained SGA prophage type. Our results indicate that whilst the dominant clonal groups of HA- and CA-MRSA belong to SCCmec type III and carry ccr type 3 genes, several distinct but less prevalent types of CA-MRSA carrying SCCmec type IVa, c and type 2 ccr are also found in Tehran. These strains carry pvl genes and SGA prophage type, a characteristic that may be used as a marker for detection of CA-MRSA in this country.

Details

Title: Characteristics of hospital and community-acquired methicillin resistant Staphylococcus aureus in Tehran, Iran
Authors: Fateh Rahimi (Author) - University of Isfahan, Iran
Mohammad Katouli (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and Engineering
Mohammad Reza Pourshafie (Author) - Pasteur Institute of Iran, Iran
Publication details: Journal of Medical Microbiology, Vol.63(6), pp.796-804
Publisher: Society for General Microbiology
Date published: 2014
DOI: 10.1099/jmm.0.070722-0
ISSN: 0022-2615
Copyright note: Copyright © 2014 The Author. The accepted manuscript is reproduced in accordance with the copyright policy of the publisher. The definitive version is available at http://dx.doi.org/10.1099/jmm.0.070722-0
Organisation Unit: University of the Sunshine Coast, Queensland; School of Health and Sport Sciences - Legacy; School of Science, Technology and Engineering; Centre for Bioinnovation
Language: English
Record Identifier: 99448929502621
Output Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Web Of Science research areas: Microbiology

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