Files and links (2)
Accepted VersionCC BY-NC-ND V4.0, Open Access
Journal article
Characterising mental wellbeing and associations with subcortical grey matter volume at short intervals in early adolescence
Developmental Cognitive Neuroscience, Vol.72, pp.1-11
2025
Appears in Thompson Institute Research Collection
Abstract
This temporally rich, longitudinal study of early adolescents (N=88, 277 datasets, 12-13 years) investigated the relationship between bilateral subcortical grey matter volume (GMV) in the hippocampus, amygdala, accumbens-area, caudate, putamen and pallidum with self-reported mental wellbeing at four timepoints, across 12 months. Generalised Estimating Equations (GEE) revealed (1) higher ‘total wellbeing’ was associated with smaller left caudate and larger left accumbens-area; (2) higher eudaimonic wellbeing was associated with smaller left caudate and larger right caudate; and (3) higher hedonic wellbeing was associated with larger left accumbens-area. Further analyses and plots highlighted different associations between GMV and wellbeing for adolescents who consistently experienced ‘moderate-to-flourishing’ wellbeing (n=63, 201 datasets), compared with those who experienced ‘languishing’ wellbeing at any timepoint (n=25, 76 datasets). These findings demonstrate several associations between subcortical GMV and measures of wellbeing, at short intervals in early adolescence. Taken together, sub-types of wellbeing appear uniquely associated with specific subcortical regions; and there may be a distinct neurobiological and wellbeing profile for adolescents who experience poorer wellbeing over the course of their first year(s) of secondary school. This study implicates the bilateral caudate and left accumbens-area as important targets for future research into the mental wellbeing of adolescents.
Details
- Title
- Characterising mental wellbeing and associations with subcortical grey matter volume at short intervals in early adolescence
- Authors
- Amanda Boyes (Corresponding Author) - University of the Sunshine Coast, Queensland, Thompson InstituteJacob M. Levenstein - University of the Sunshine Coast, Queensland, Thompson InstituteLarisa T. McLoughlin - University of the Sunshine Coast, Queensland, Thompson InstituteChristina Driver - University of the Sunshine Coast, Queensland, Thompson InstituteDashiell D. Sacks - University of the Sunshine Coast, Queensland, Thompson InstituteKassie Bromley - University of the Sunshine Coast, Queensland, Thompson InstituteTaliah Prince - University of the Sunshine Coast, Queensland, Thompson InstituteJustine M. Gatt - UNSW SydneyJim Lagopoulos - University of the Sunshine Coast, Queensland, Thompson InstituteDaniel F. Hermens - University of the Sunshine Coast, Queensland, Thompson Institute
- Publication details
- Developmental Cognitive Neuroscience, Vol.72, pp.1-11
- Publisher
- Elsevier Ltd
- Date published
- 2025
- DOI
- 10.1016/j.dcn.2024.101498
- ISSN
- 1878-9307; 1878-9293
- Organisation Unit
- Graduate Research School; Thompson Institute
- Language
- English
- Record Identifier
- 991091101702621
- Output Type
- Journal article
Metrics
8 File views/ downloads
41 Record Views