Files and links (1)
Ophthalmic Physiologic Optic - 2023 - Tong - Characterisation of the normal human ganglion cell inner plexiform layer using6.63 MB
Published VersionCC BY V4.0, Open Access
Journal article
Characterisation of the normal human ganglion cell-inner plexiform layer using widefield optical coherence tomography
Ophthalmic and Physiological Optics, Vol.44(2), pp.457-471
2024
Abstract
Purpose:
To describe variations in ganglion cell–inner plexiform layer (GCIPL) thickness in a healthy cohort from widefield optical coherence tomography (OCT) scans.
Methods:
Widefield OCT scans spanning 55° × 45° were acquired from 470 healthy eyes. The GCIPL was automatically segmented using deep learning methods. Thickness measurements were extracted after correction for warpage and retinal tilt. Multiple linear regression analysis was applied to discern trends between global GCIPL thickness and age, axial length and sex. To further characterise age-related change, hierarchical and two-step cluster algorithms were applied to identify locations sharing similar ageing properties, and rates of change were quantified using regression analyses with data pooled by cluster analysis outcomes.
Results:
Declines in widefield GCIPL thickness with age, increasing axial length and female sex were observed (parameter estimates −0.053, −0.436 and −0.464, p-values <0.001, <0.001 and 0.02, respectively). Cluster analyses revealed concentric, slightly nasally displaced, horseshoe patterns of age-related change in the GCIPL, with up to four statistically distinct clusters outside the macula. Linear regression analyses revealed significant ageing decline in GCIPL thickness across all clusters, with faster rates of change observed at central locations when expressed as absolute (slope = −0.19 centrally vs. −0.04 to −0.12 peripherally) and percentage rates of change (slope = −0.001 centrally vs. −0.0005 peripherally).
Conclusions:
Normative variations in GCIPL thickness from widefield OCT with age, axial length and sex were noted, highlighting factors worth considering in further developments. Widefield OCT has promising potential to facilitate quantitative detection of abnormal GCIPL outside standard fields of view.
Details
- Title
- Characterisation of the normal human ganglion cell-inner plexiform layer using widefield optical coherence tomography
- Authors
- Janelle Tong (Author) - UNSW SydneyDavid Alonso-Caneiro (Author) - University of the Sunshine Coast, Queensland, School of Science, Technology and EngineeringJason Kugelman (Author) - Queensland University of TechnologyJack Phu (Author) - UNSW SydneySieu K Khuu (Author) - UNSW SydneyMichael Kalloniatis (Corresponding Author) - UNSW Sydney
- Publication details
- Ophthalmic and Physiological Optics, Vol.44(2), pp.457-471
- Publisher
- Wiley-Blackwell Publishing Ltd.
- Date published
- 2024
- DOI
- 10.1111/opo.13255
- ISSN
- 1475-1313; 0275-5408
- Copyright note
- © 2023 The Authors. Ophthalmic and Physiological Optics published by John Wiley & Sons Ltd on behalf of College of Optometrists. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
- Organisation Unit
- School of Science, Technology and Engineering
- Language
- English
- Record Identifier
- 99981191002621
- Output Type
- Journal article
Metrics
51 Record Views