Journal article
Changing prevalence of aetiological factors and comorbidities among Australians hospitalised for cirrhosis
Internal Medicine Journal, Vol.51(5), pp.691-698
2020
PMID: 32096890
Abstract
Background: The rate of hospital admissions for cirrhosis increased 1.3-fold during 2008-2016 in Queensland. Alcohol misuse was a contributing factor for cirrhosis in 55% of admissions and 40% of patients had at least one comorbidity.
Aims: To examine the temporal change in aetiology of liver disease and presence of comorbidity in patients admitted with cirrhosis.
Methods: Population-based retrospective cohort study of all people treated in hospital for cirrhosis (10 254 patients) in Queensland during 2008-2016. Data were sourced from Queensland Hospital Admitted Patient Data Collection.
Results: The commonest aetiology was alcohol (49.5%), followed by cryptogenic (unspecified cirrhosis; 28.5%), hepatitis C virus (19.3%), non-alcoholic fatty liver disease (NAFLD)/non-alcoholic steatohepatitis (NASH) (4.8%) and hepatitis B virus (HBV) (4.3%). The prevalence of alcohol-related (P = 0.41) and hepatitis C virus (P = 0.08) remained stable between 2008-2010 and 2014-2016, that of NAFLD/NASH, cryptogenic and HBV-cirrhosis increased by 67% (P < 0.00001), 27% (P < 0.00001) and 20% (P = 0.00019), respectively; 41.1% of patients had at least one comorbidity. The prevalence of type 2 diabetes nearly doubled (from 13.7% to 25.4%; P < 0.00001) between 2008-2010 and 2014-2016.
Conclusions: Alcohol misuse was the most important aetiology. The importance of NAFLD/NASH, cryptogenic and HBV-cirrhosis and the burden of comorbidity increased during 2008-2016. Ongoing alcohol misuse and the increasing prevalence of NAFLD/NASH, cryptogenic cirrhosis and comorbid type 2 diabetes among admissions for cirrhosis has implications for public health interventions to reduce the burden of unhealthy lifestyle and metabolic disorders.
Details
- Title
- Changing prevalence of aetiological factors and comorbidities among Australians hospitalised for cirrhosis
- Authors
- Patricia C Valery (Corresponding Author) - QIMR Berghofer Medical Research InstituteSteven McPhail (Author) - Queensland University of TechnologyKatherine A Stuart (Author) - Princess Alexandra HospitalGunter Hartel (Author) - QIMR Berghofer Medical Research InstitutePaul J Clark (Author) - Mater Private HospitalJames O'Beirne (Author) - Sunshine Coast University HospitalRichard Skoien (Author) - Royal Brisbane and Women's HospitalTony Rahman (Author) - Prince Charles HospitalChris Moser (Author) - Queensland HealthElizabeth E Powell (Author) - Princess Alexandra Hospital
- Publication details
- Internal Medicine Journal, Vol.51(5), pp.691-698; 8
- Publisher
- Wiley-Blackwell Publishing Asia
- Date published
- 2020
- DOI
- 10.1111/imj.14809
- ISSN
- 1445-5994
- PMID
- 32096890
- Copyright note
- This is the peer reviewed version of the following article: Valery, P.C., McPhail, S., Stuart, K.A., Hartel, G., Clark, P.J., O'Beirne, J., Skoien, R., Rahman, T., Moser, C. and Powell, E.E. (2021), Changing prevalence of aetiological factors and comorbidities among Australians hospitalised for cirrhosis. Intern Med J, 51: 691-698. https://doi.org/10.1111/imj.14809, which has been published in final form at https://doi.org/10.1111/imj.14809. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited
- Organisation Unit
- UniSC Clinical Trials Centre; University of the Sunshine Coast, Queensland; School of Health and Behavioural Sciences - Legacy
- Language
- English
- Record Identifier
- 99534605602621
- Output Type
- Journal article
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