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Changes in retinal and choroidal optical coherence tomography angiography indices among young adults and children over 1 year5.64 MB
Published VersionCC BY-NC-ND V4.0, Open Access
Journal article
Changes in retinal and choroidal optical coherence tomography angiography indices among young adults and children over 1 year
Clinical and Experimental Optometry, Vol.107(6), pp.627-634
2024
Abstract
Clinical relevance: Optical coherence tomography angiography (OCT-A) indices are likely to change across time and optometrists should be aware of the variability expected during childhood development and in healthy adults.
Background: Cross-sectional studies have shown that OCT-A indices are associated with age in adults and children. The aim of this study is to investigate longitudinal changes in retinal and choroidal OCT-A indices over 1 year among healthy children and young adults.
Methods: This prospective longitudinal study captured macular OCT-A and OCT scans, and biometry measures at baseline and 1-year follow-up for 22 adults (18-30 years; -6.87 to +0.37 D) and 21 children
(6-15 years; -5.75 to +0.25 D). Superficial and deep retinal layer, choriocapillaris and deep choroidal en face OCT-A images were analysed to extract magnification-corrected vascular indices in foveal, parafoveal and perifoveal regions. The retinal indices included foveal avascular zone metrics, perfusion, and vessel density. Flow deficit number, size, and density were extracted from choriocapillaris and perfusion density from deep choroid. Associations between annual changes in the OCT-A indices and axial length and baseline refraction were also studied.
Results: Among children, significant reductions were noted only in parafoveal superficial retinal and foveal and perifoveal deep retinal layer indices over 1 year (p < 0.05). Choroidal OCT-A indices in children and both retinal and choroidal OCT-A indices in adults did not show significant changes. Myopia was associated with a larger reduction in the perifoveal retinal OCT-A indices in children, and with increases in
sub-foveal and sub-parafoveal choroidal indices in adults. There were associations between OCT-A indices and axial length changes but differently in adults and children.
Conclusions: Significant changes were noted in retinal OCT-A indices over 1 year among children but not adults. In comparison, choroidal OCT-A indices in adults and children showed a stable morphology over this period of time.
Details
- Title
- Changes in retinal and choroidal optical coherence tomography angiography indices among young adults and children over 1 year
- Authors
- Barsha Lal (Corresponding Author) - Queensland University of TechnologyDavid Alonso-Caneiro (Author) - University of the Sunshine Coast, Queensland, School of Science, Technology and EngineeringScott A Read (Author) - Queensland University of TechnologyAndrew Carkeet (Author) - Queensland University of Technology
- Publication details
- Clinical and Experimental Optometry, Vol.107(6), pp.627-634
- Publisher
- Taylor & Francis
- Date published
- 2024
- DOI
- 10.1080/08164622.2023.2259907
- ISSN
- 1444-0938; 0816-4622
- Copyright note
- This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4. 0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.
- Organisation Unit
- University of the Sunshine Coast, Queensland; School of Science, Technology and Engineering
- Language
- English
- Record Identifier
- 99971186202621
- Output Type
- Journal article
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- Domestic collaboration
- Web Of Science research areas
- Ophthalmology
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