Cerebrovascular function and its association with systemic artery function and stiffness in older adults with and without mild cognitive impairment

Tom Bailey; Timo Klein; Annelise L Meneses; Kayla Stefanidis; Stefanie Ruediger; Daniel J Green; Tim Stuckenschneider; Stefan Schneider; Christopher Askew

doi:10.1007/s00421-022-04956-w

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Cerebrovascular function and its association with systemic artery function and stiffness in older adults with and without mild cognitive impairment

Journal article

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Cerebrovascular function and its association with systemic artery function and stiffness in older adults with and without mild cognitive impairment

Tom Bailey, Timo Klein, Annelise L Meneses, Kayla Stefanidis, Stefanie Ruediger, Daniel J Green, Tim Stuckenschneider, Stefan Schneider and Christopher Askew

European Journal of Applied Physiology, Vol.122, pp.1843-1856

2022

DOI: https://doi.org/10.1007/s00421-022-04956-w

PMCID: PMC9287231

PMID: 35522276

Appears in UniSC Diversity and Inclusion Research Collection

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Abstract

cognition

dementia

pulse wave velocity

cerebral blood flow

pulsatility index

flow-mediated dilation

UniSC Diversity Area - Disability and Inclusion

UniSC Diversity Area - Life Stages

Purpose: Our aim was to compare cerebrovascular and systemic vascular function between older adults with and without mild cognitive impairment (MCI), and to determine which measures of vascular function best predict the presence of MCI. Methods: In 41 adults with MCI and 33 adults without MCI (control) we compared middle cerebral artery velocity (MCAv) and cerebrovascular pulsatility index (PI) at rest, cerebrovascular reactivity to CO2, and responsiveness to changes in blood pressure (%∆MCAv/%∆MAP). Systemic vascular function was assessed by flow-mediated dilation (FMD) and stiffness by pulse wave velocity (PWV). Results: Cerebrovascular PI was higher in MCI compared with control (mean ± SD: 1.17 ± 0.27 vs. 1.04 ± 0.21), and MCI exhibited a lower %∆MCAv/%∆MAP (1.26 ± 0.44 vs. 1.50 ± 0.55%). Absolute (p = 0.76) and relative cerebrovascular reactivity to CO2 (p = 0.34) was similar between MCI and control. When age was included as a covariate the significant difference in cerebral PI between groups was lost. PWV was higher (13.2 ± 2.2 vs. 11.3 ± 2.5 m s−1) and FMD% (4.41 ± 1.70 vs. 5.43 ± 2.15%) was lower in MCI compared with control. FMD% was positively associated with PI across the cohort. Logistic regression analysis indicated that FMD and PWV significantly discriminated between MCI and controls, independent of age, whereas the inclusion of cerebrovascular measures did not improve the predictive accuracy of the model. Conclusion: These findings raise the possibility that early changes in systemic vascular stiffness and endothelial function may contribute to altered cerebrovascular haemodynamics and impaired cognitive function, and present potential targets for prevention and treatment strategies in people with MCI.

Details

Title: Cerebrovascular function and its association with systemic artery function and stiffness in older adults with and without mild cognitive impairment
Authors: Tom Bailey (Author) - University of the Sunshine Coast, Queensland, School of Health and Sport Sciences - Legacy
Timo Klein (Author) - University of the Sunshine Coast, Queensland, School of Health and Sport Sciences - Legacy
Annelise L Meneses (Author) - University of the Sunshine Coast, Queensland, School of Health and Sport Sciences - Legacy
Kayla Stefanidis (Author) - University of the Sunshine Coast, Queensland, School of Law and Society
Stefanie Ruediger (Author) - The University of Queensland
Daniel J Green (Author) - The University of Western Australia
Tim Stuckenschneider (Author) - University of the Sunshine Coast, Queensland, School of Health and Behavioural Sciences - Legacy
Stefan Schneider (Author) - University of the Sunshine Coast, Queensland, School of Health and Sport Sciences - Legacy
Christopher Askew (Corresponding Author) - University of the Sunshine Coast, Queensland, School of Health and Behavioural Sciences - Legacy
Publication details: European Journal of Applied Physiology, Vol.122, pp.1843-1856
Publisher: Springer
Date published: 2022
DOI: 10.1007/s00421-022-04956-w
ISSN: 1439-6327
PMID: 35522276; PMC9287231
Copyright note: This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
Organisation Unit: Road Safety Research Collaboration; UniSC Clinical Trials Centre; University of the Sunshine Coast, Queensland; School of Health and Sport Sciences - Legacy; Cancer Research Cluster; School of Health - Sports & Exercise Science; School of Law and Society; School of Health and Behavioural Sciences - Legacy
Language: English
Record Identifier: 99629438902621
Output Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
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