Cerebrovascular autoregulation as a neuroimaging tool

Jim Lagopoulos; Gin S Malhi; Belinda Ivanovski; Catherine M Cahill; Erhard W Lang; Yugan Mudaliar; Nick Dorsch; Alan Yam; Jane Griffith; Jamin Mulvey

doi:10.1111/j.1601-5215.2006.00133.x

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Cerebrovascular autoregulation as a neuroimaging tool

Journal article

Peer reviewed

Cerebrovascular autoregulation as a neuroimaging tool

Jim Lagopoulos, Gin S Malhi, Belinda Ivanovski, Catherine M Cahill, Erhard W Lang, Yugan Mudaliar, Nick Dorsch, Alan Yam, Jane Griffith and Jamin Mulvey

Acta Neuropsychiatrica, Vol.18(2), pp.100-104

2006

DOI: https://doi.org/10.1111/j.1601-5215.2006.00133.x

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Abstract

Medical and Health Sciences

Psychology and Cognitive Sciences

BOLD

cerebrovascular autoregulation

fMRI

fTCD

Functional transcranial Doppler (fTCD) sonography provides a high temporal resolution measure of blood flow and has over the years proved to be a valuable tool in the clinical evaluation of patients with cerebrovascular disorders. More recently, due to advances in physics and computing, it has become possible to derive indices of cerebrovascular autoregulation (CA) as well as cerebrovascular pressure reactivity (CR), using non-invasive techniques. These indices provide a dynamic representation of the brain's regulatory blood flow mechanisms not only in pathological states but also in health. However, whilst the temporal resolution of these regulatory indices is very good, spatially, the localization of brain regions remains very poor, thus limiting its brain mapping capacity. Functional MRI, on the contrary, is a brain-imaging technique that operates on similar blood flow principles; however, unlike fTCD, it provides high spatial resolution. Because both fTCD and fMRI determine blood flow-dependant imaging parameters, the coupling of fTCD with fMRI may provide greater insight into brain function by virtue of the combined enhanced temporal and spatial resolution that each technique affords. This review summarizes the fTCD technique with particular emphasis on the CA and CR indices and their relationship in traumatic brain injury as well as in health.

Details

Title: Cerebrovascular autoregulation as a neuroimaging tool
Authors: Jim Lagopoulos (Author) - University of New South Wales
Gin S Malhi (Author) - University of New South Wales
Belinda Ivanovski (Author) - University of New South Wales
Catherine M Cahill (Author) - University of New South Wales
Erhard W Lang (Author) - Westmead Hospital
Yugan Mudaliar (Author) - Westmead Hospital
Nick Dorsch (Author) - Westmead Hospital
Alan Yam (Author) - Westmead Hospital
Jane Griffith (Author) - Westmead Hospital
Jamin Mulvey (Author) - Westmead Hospital
Publication details: Acta Neuropsychiatrica, Vol.18(2), pp.100-104
Publisher: Cambridge University Press
Date published: 2006
DOI: 10.1111/j.1601-5215.2006.00133.x
ISSN: 0924-2708
Organisation Unit: University of the Sunshine Coast, Queensland; Thompson Institute
Language: English
Record Identifier: 99450705302621
Output Type: Journal article

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Collaboration types: Domestic collaboration
Web Of Science research areas: Neurosciences; Psychiatry

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