Cerebral autoregulation and ageing

A T Yam; E W Lang; Jim Lagopoulos; K Yip; J Griffith; Y Mudaliar; N W Dorsch

doi:10.1016/j.jocn.2004.08.017

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Journal article

Peer reviewed

Cerebral autoregulation and ageing

A T Yam, E W Lang, Jim Lagopoulos, K Yip, J Griffith, Y Mudaliar and N W Dorsch

Journal of Clinical Neuroscience, Vol.12(6), pp.643-646

2005

DOI: https://doi.org/10.1016/j.jocn.2004.08.017

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Abstract

comparative study

cerebral autoregulation

ageing

cerebral blood flow velocity

transcranial Doppler ultrasound

Little is known about the effects of ageing on cerebral autoregulation (CA). To examine the relationship between age and CA in adults, we conducted a prospective study using a non-invasive protocol without external stimuli. We studied 32 subjects, aged 23-68 years. They were assigned to a young group (28±5 years) and an old group (54±8 years). The groups were sex-matched. Transcranial Doppler ultrasonography (TCD) was used to record bilateral middle cerebral artery flow velocities (CBFV, cm/sec). Noninvasive beat-to-beat tonometric arterial blood pressure (ABP) measurement of the radial artery was used to record spontaneous blood pressure fluctuations. The Mx, an index of dynamic cerebral autoregulation (dCA), was calculated from a moving correlation between ABP and CBFV. We did not find a correlation between age and Mx. No statistically significant difference in the Mx between the groups (0.27±0.23, young, vs. 0.37±0.24, old) was demonstrated. Age does not affect dynamic cerebral autoregulation assessed by the Mx index in healthy adult subjects. This study supports findings from previous papers wherein CA was measured with protocols which require external stimuli. Further studies are needed to determine CA in subjects above 70 years of age. © 2005 Elsevier Ltd. All rights reserved.

Details

Title: Cerebral autoregulation and ageing
Authors: A T Yam (Author) - University of Sydney
E W Lang (Author) - University of Sydney
Jim Lagopoulos (Author) - University of Sydney
K Yip (Author) - University of Sydney
J Griffith (Author) - University of Sydney
Y Mudaliar (Author) - University of Sydney
N W Dorsch (Author) - University of Sydney
Publication details: Journal of Clinical Neuroscience, Vol.12(6), pp.643-646
Publisher: Oxford University Press
Date published: 2005
DOI: 10.1016/j.jocn.2004.08.017
ISSN: 0967-5868
Organisation Unit: University of the Sunshine Coast, Queensland; Thompson Institute
Language: English
Record Identifier: 99449498102621
Output Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Web Of Science research areas: Clinical Neurology; Neurosciences

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